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      Innervation Pattern and Neurogenic Response of Rabbit Veins

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          Abstract

          The adrenergic neuroeffector mechanism has been assessed in 14 different veins of the rabbit chosen to represent vessels of different, function and regional location. The pattern, distribution and density of the adrenergic innervation were assessed by fluorescence histochemistry. The magnitude of the neurogenic contractile response of isolated segments was studied in vitro in relation to the maximum response to 1-norepinephrine. The diameter and wall thickness of the veins was determined. The amount of adrenergic innervation determined histochemically was related to the size of the contractile response. Both fluorescence and response were absent in the superficial cervical, femoral, subcutaneous from back, brachial and deep circumflex iliac branch veins. The amount of adrenergic innervation increased in order in the renal, inferior vena cava, pulmonary, jugular, parietal branch of internal iliac, mesenteric, central ear, cephalic and small saphenous veins. In the latter two veins, innervation was not restricted to the adventitio-medial junction but entered the media. The pattern of innervation and contractile response may be related to the functional need for active venoconstriction in the various parts of the capacitance section of the vascular system.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 3
          : 172-182
          Affiliations
          Departments of Pharmacology and Biomathematics, Center for Health Sciences, School of Medicine, UCLA, Los Angeles, Calif.
          Article
          158010 Blood Vessels 1974;11:172–182
          10.1159/000158010
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Research Paper

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