C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy.

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Abstract

IgA nephropathy (IgAN) is the most common primary kidney disease, often leading to chronic renal failure. Complement activation products C3a and C5a have broad pro-inflammatory potential through their receptors, C3aR and C5aR, and contribute to the pathogenesis of several inflammatory and autoimmune diseases, but their roles in IgAN are poorly defined.

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Journal

Journal ID (iso-abbrev): J. Clin. Immunol.

Title: Journal of clinical immunology

ISSN (Electronic): 1573-2592

ISSN (Print): 0271-9142

Publication date (Electronic): Feb 2014

Volume: 34

Issue: 2

Affiliations

[1 ] Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou University Institute of Nephrology, Zhengzhou, 450052, China.

Article

DOI: 10.1007/s10875-013-9970-6

PubMed ID: 24327134

SO-VID: 1ecc5c7d-4f7f-4fe6-a9f4-f9954cff3e58

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