The concept of a Microstructured Optical Fiber-based Surface Plasmon Resonance sensor with optimized microfluidics is proposed. In such a sensor plasmons on the inner surface of large metallized channels containing analyte can be excited by a fundamental mode of a single mode microstructured fiber. Phase matching between plasmon and a core mode can be enforced by introducing air filled microstructure into the fiber core, thus allowing tuning of the modal refractive index and its matching with that of a plasmon. Integration of large size microfluidic channels for efficient analyte flow together with a single mode waveguide of designable effective refractive index is attractive for the development of integrated highly sensitive MOF-SPR sensors operating at any designable wavelength.