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Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
Kieren G. Hollingsworth ,
Julia L. Newton ,
Lisa Robinson ,
Roy Taylor ,
Andrew M. Blamire ,
David E.J. Jones
July 2010
July 2010
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Abstract
Upon exercise, primary biliary cirrhosis (PBC) is associated with significant acidosis
in peripheral muscle with recovery rate from acidosis strongly associating with fatigue.
PBC patients describe particular problems with repeat exercise describing subsequent
exercise episodes being limited by perceived effects of the first. We modelled this
effect by exploring kinetics of pH recovery during 3 linked exercise episodes using
magnetic resonance spectroscopy (MRS).