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The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease.
C Büning
1 ,
J Ockenga ,
S Krüger ,
J Jurga ,
P Baier ,
A Dignass ,
A Vogel ,
C Strassburg ,
R Weltrich ,
J Genschel ,
H Lochs ,
H Schmidt
May 2003
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Abstract
Lactose intolerance with adult-onset is due to the inadequate enzymatic activity of lactasephlorizin hydrolase (LPH). It is frequently seen in patients with Crohn disease, but the mechanism remains to be elucidated. Two DNA genotypes, C/C(-13910) and G/G(-22018), located upstream from the LCT locus, the gene encoding for LPH, were recently identified as representing genetic markers for lactose intolerance. We utilized these two DNA genotypes to study their role in inflammatory bowel disease.