Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Lee, Jin-Ku; Wang, Jiguang; Sa, Jason K.; Ladewig, Erik; Lee, Hae-ock; Lee, In-Hee; Kang, Hyun Ju; Rosenbloom, Daniel S; Camara, Pablo G.; Liu, Zhaoqi; Nieuwenhuizen, Patrick van; Jung, Sang-Won; Choi, Seung-Won; Kim, Junhyung; Chen, Andrew; Kim, Kyu-Tae; SHIN, Sang-Min; Seo, Yun Jee; Oh, Jin Mi; Shin, Yong Jae; Park, Chul-Kee; Kong, Doo-Sik; Seol, Ho Jun; Blumberg, Andrew J.; Lee, Jung-Il; Iavarone, Antonio; Park, Woong-Yang; Rabadan, Raul; Nam, Do-Hyun

doi:10.1038/ng.3806

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Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Author(s): Jin-Ku Lee , Jiguang Wang , Jason K Sa , Erik Ladewig , Hae-Ock Lee , In-Hee Lee , Hyun Ju Kang , Daniel S Rosenbloom , Pablo G Camara , Zhaoqi Liu , Patrick van Nieuwenhuizen , Sang Won Jung , Seung Won Choi , Junhyung Kim , Andrew Chen , Kyu-Tae Kim , Sang Shin , Yun Jee Seo , Jin-Mi Oh , Yong Jae Shin , Chul-Kee Park , Doo-Sik Kong , Ho Jun Seol , Andrew Blumberg , Jung-Il Lee , Antonio Iavarone , Woong-Yang Park , Raul Rabadan , Do-Hyun Nam

Publication date Created: March 6 2017

Publication date (Print): March 6 2017

Journal: Nature Genetics

Publisher: Springer Nature

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Abstract

Raul Rabadan, Woong-Yang Park, Do-Hyun Nam and colleagues examine the genomic and transcriptomic profiles of tumors from 52 patients with glioblastoma using both bulk and single-cell analyses. They find that tumors that are isolated from distinct locations or at different times are seeded from different clones, suggesting the need for multisector biopsies.

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The National Institutes of Health have placed significant emphasis on sharing of research data to support secondary research. Investigators have been encouraged to publish their clinical and imaging data as part of fulfilling their grant obligations. Realizing it was not sufficient to merely ask investigators to publish their collection of imaging and clinical data, the National Cancer Institute (NCI) created the open source National Biomedical Image Archive software package as a mechanism for centralized hosting of cancer related imaging. NCI has contracted with Washington University in Saint Louis to create The Cancer Imaging Archive (TCIA)-an open-source, open-access information resource to support research, development, and educational initiatives utilizing advanced medical imaging of cancer. In its first year of operation, TCIA accumulated 23 collections (3.3 million images). Operating and maintaining a high-availability image archive is a complex challenge involving varied archive-specific resources and driven by the needs of both image submitters and image consumers. Quality archives of any type (traditional library, PubMed, refereed journals) require management and customer service. This paper describes the management tasks and user support model for TCIA.

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Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

Matija Snuderl, Ladan Fazlollahi, Long P. Le … (2011)

Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in human malignant brain tumors in which multiple closely related driver genes are amplified and activated simultaneously in adjacent intermingled cells. We have observed up to three different receptor tyrosine kinases (EGFR, MET, PDGFRA) amplified in single tumors in different cells in a mutually exclusive fashion. Each subpopulation was actively dividing, and the genetic changes resulted in protein production, and coexisting subpopulations shared common early genetic mutations indicating their derivation from a single precursor cell. The stable coexistence of different clones within the same tumor will have important clinical implications for tumor resistance to targeted therapies. Copyright © 2011 Elsevier Inc. All rights reserved.