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      Electrophysiological Effects of Lidocaine in Acute Myocardial Infarction with Bifascicular Block or Complete A-V Block

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          Abstract

          Electrophysiological effects of lidocaine were studied in 27 patients with acute myocardial infarction complicated by bifascicular block (group I: 20), and complete A-V block (group II: 7). Lidocaine was administered intravenously in bolus doses of 100 mg each at intervals of 10 min. In group I, there was no significant change in the heart rate (Before (B) = 84.85 ± 24.19, After (A) = 87.25 ± 20.26 beats/min) intra-atrial (PA) conduction time (B = 25 ± 6.18, A = 27.22 ± 6.69 ms), A-V nodal (AH) conduction (B = 111.5 ± 56.12, A= 111.5 ± 56.5 ms) or His bundle to ventricular (HV) activation time (B = 59.5 ± 19.32, A = 61.25 ± 18.62 ms) after lidocaine administration. In group II, 2 patients reverted to sinus rhythm, one with 1:1 conduction and the other with type II Wenckebach’s block, while being prepared for the study, but both had complete A-V block within 1 h of the His bundle electrogram recordings. Of the remaining 5 patients, 4 had supra and 1 infra His A-V block. After lidocaine, 2 patients developed asystole. In the remaining 4 patients, there was no change in the escape rate or various conduction intervals.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1983
          1983
          07 November 2008
          : 70
          : 6
          : 333-340
          Affiliations
          Division of Cardiology, Medical Department I, Sahlgrenska Hospital, Göteborg, Sweden
          Article
          173616 Cardiology 1983;70:333–340
          10.1159/000173616
          6673827
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Case Report

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