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      Management of patients with condylar hyperplasia: A diverse experience with 18 patients

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          Abstract

          Purpose:

          The purpose was to report the clinical experience with patients diagnosed with Condylar Hyperplasia (CH).

          Materials and Methods:

          Eighteen patients with CH underwent condylar growth assessment using clinical and radiographic examinations. Seven patients with suspected active condyles underwent single photo emission computed tomography (SPECT) examination. A total of patients with asymmetry and malocclusion were treated with orthognathic surgery. Three patients with intact occlusion; underwent inferior border osteotomy with nerve repositioning. All patients were followed up for 3 years without any complications.

          Conclusion:

          There is great diversity in the clinical and radiographic presentation in cases with CH. Assessment of condylar growth activity is the cornerstone in managing these cases. After that each case has its own diverse treatment plan to achieve a satisfactory facial symmetry.

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          Hemimandibular hyperplasia--hemimandibular elongation.

          H Obwegeser, M S Makek (1986)
          Clinical and radiographic experience as well as histological findings leave no doubt that the term "condylar hyperplasia" refers only to hyperplasia of the condyle alone and should therefore not be used to mean the two hemimandibular anomalies as is the case in the literature today. There are two basically different malformations of one side of the mandible which we call hemimandibular hyperplasia and hemimandibular elongation respectively. We are convinced that there exist pure and mixed forms of both growth anomalies because we have observed several such clinical cases. The stimulus for the abnormal growth either lies within the fibrocartilaginous layer or is produced by it. Different histological patterns within the condylar growth zone were seen in the two anomalies. The pathophysiological bases of the abnormal growth are discussed. They seem to contribute to the understanding of the normal and abnormal mandibular growth and consequently also of many of the mandibular anomalies. The explanations are demonstrated by the illustrations of some cases.
          Article 0 comments Cited 35 times – based on 0 reviews     Review now
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            Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder.

            Margarete Ribeiro-Dasilva, Sérgio Peres Line, Maria Leme Godoy dos Santos … (2009)
            Temporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (XbaI/PvuII) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and 100 control women without TMJD. Restriction fragment length polymorphisms of polymerase chain reaction products were used to analyze XbaI and PvuII SNPs in DNA fragments. A model directly characterizing specific DNA sequence variants based on the risk haplotypic structure implemented with the EM algorithm was used to analyze the data. The [GC] haplotype of the XbaI locus was significantly more prevalent in both TMJD groups when compared with the control group (P = .0012). Specifically, the [GC] haplotype was more prevalent within the painful TMJD group versus the control group (OR = 3.203, 95% CI = 1.633, 6.284) and in the TMJD no pain versus the control group (OR = 2.51, 95% CI = 1.267, 4.97). In conclusion, the presence of [GC] haplotype in the XbaI locus may increase the susceptibility of women to develop TMJD. This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. This finding may elucidate the interindividual differences in the contribution of estrogen to TMJD, the genetic influences on TMJD predisposition, and may serve as the basis for future treatment tailoring, which could enhance outcomes for these patients.
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              The clinical characteristics of condylar hyperplasia: experience with 61 patients.

              Dorrit Nitzan, Alex Katsnelson, Ido Bermanis … (2008)
              Much reported variation and discord exist regarding mandibular condylar hyperplasia (CH). This study evaluated some of the characteristics of this disorder in a series of 61 patients with active CH.
              Article 0 comments Cited 29 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Ann Maxillofac Surg
                Journal ID (iso-abbrev): Ann Maxillofac Surg
                Journal ID (publisher-id): AMS
                Title: Annals of Maxillofacial Surgery
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 2231-0746
                ISSN (Electronic): 2249-3816
                Publication date (Print): Jan-Jun 2012
                Volume: 2
                Issue: 1
                Pages: 17-23
                Affiliations
                [1]Department of Oral and Maxillofacial Surgery, King Abdulaziz University, Jeddah, Saudi Arabia
                Author notes
                Address for correspondence: Dr. Sondos Abuzinada, Department of Oral and Maxillofacial Surgery, King Abdulaziz University, Jeddah, Saudi Arabia. E-mail: sondoz@ 123456hotmail.com
                Article
                Publisher ID: AMS-2-17
                DOI: 10.4103/2231-0746.95311
                PMC ID: 3591071
                PubMed ID: 23483790
                SO-VID: 1fb82504-c6b6-488f-ae0a-450d8ab0234f
                Copyright © Copyright: © Annals of Maxillofacial Surgery
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Subject: Original Clinical Studies

                Keywords: condylar hyperplasia,facial asymmetry,hemimandibular elongation,hemimandibular hypertrophy
                Data availability:
                Keywords: condylar hyperplasia, facial asymmetry, hemimandibular elongation, hemimandibular hypertrophy

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