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The Pfam protein families database
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Abstract
Pfam is a large collection of protein families and domains. Over the past 2 years
the number of families in Pfam has doubled and now stands at 6190 (version 10.0).
Methodology improvements for searching the Pfam collection locally as well as via
the web are described. Other recent innovations include modelling of discontinuous
domains allowing Pfam domain definitions to be closer to those found in structure
databases. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/),
the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/).