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      Biodegradable Materials and Metallic Implants—A Review

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          Abstract

          Recent progress made in biomaterials and their clinical applications is well known. In the last five decades, great advances have been made in the field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics and metal alloys. A variety of bioimplants are currently used in either one of the aforesaid forms. Some of these materials are designed to degrade or to be resorbed inside the body rather than removing the implant after its function is served. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, and corrosion rate and scaffold design are taken into consideration. The current review focuses on state-of-the-art biodegradable bioceramics, polymers, metal alloys and a few implants that employ bioresorbable/biodegradable materials. The essential functions, properties and their critical factors are discussed in detail, in addition to their challenges to be overcome.

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          Most cited references115

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          Synthetic biodegradable polymers as orthopedic devices

          Polymer scientists, working closely with those in the device and medical fields, have made tremendous advances over the past 30 years in the use of synthetic materials in the body. In this article we will focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired. The materials with the greatest history of use are the poly(lactides) and poly(glycolides), and these will be covered in specific detail. The chemistry of the polymers, including synthesis and degradation, the tailoring of properties by proper synthetic controls such as copolymer composition, special requirements for processing and handling, and mechanisms of biodegradation will be covered. An overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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            An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering

            Poly(lactic-co-glycolic) acid (PLGA) has attracted considerable interest as a base material for biomedical applications due to its: (i) biocompatibility; (ii) tailored biodegradation rate (depending on the molecular weight and copolymer ratio); (iii) approval for clinical use in humans by the U.S. Food and Drug Administration (FDA); (iv) potential to modify surface properties to provide better interaction with biological materials; and (v) suitability for export to countries and cultures where implantation of animal-derived products is unpopular. This paper critically reviews the scientific challenge of manufacturing PLGA-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering. The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.
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              Degradable biomaterials based on magnesium corrosion

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                Author and article information

                Journal
                J Funct Biomater
                J Funct Biomater
                jfb
                Journal of Functional Biomaterials
                MDPI
                2079-4983
                26 September 2017
                December 2017
                : 8
                : 4
                : 44
                Affiliations
                [1 ]CNRS, Univ. Bordeaux, ICMCB, UPR 9048, F-33600 Pessac, France; alain.largeteau@ 123456icmcb.cnrs.fr
                [2 ]Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, LV-1007 Riga, Latvia; janis.locs@ 123456rtu.lv (J.L.); kristine.salma-ancane@ 123456rtu.lv (K.S.-A.); dagnija.loca@ 123456rtu.lv (D.L.); liga@ 123456ktf.rtu.lv (L.B.-C.)
                Author notes
                [* ]Correspondence: mythili.prakasam@ 123456icmcb.cnrs.fr ; Tel.: +33-540-008-435; Fax: +33-540-002-761
                [†]

                These authors contributed equally to this work.

                Article
                jfb-08-00044
                10.3390/jfb8040044
                5748551
                28954399
                202e8ac0-a85d-4f80-bf21-c942051806cb
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 26 July 2017
                : 16 September 2017
                Categories
                Review

                bioceramics,biocomposites,biodegradable metal alloys,bioimplants

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