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      Role of Cilostazol in Prevention of Vasospasm After Aneurysmal Subarachnoid Hemorrhage-A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.

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          Abstract

          Cerebral vasospasm is a common complication after aneurysmal subarachnoid hemorrhage (aSAH). Many drugs have been tried to mitigate cerebral vasospasm and delayed cerebral ischemia. Cilostazol, a selective inhibitor of phosphodiesterase 3, is a promising agent in preventing cerebral vasospasm and delayed cerebral ischemia after aSAH. The objective of this article was to ascertain the effect of cilostazol on cerebral vasospasm after aSAH by performing meta-analysis and trial sequential analysis.

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          Author and article information

          Journal
          World Neurosurg
          World neurosurgery
          Elsevier BV
          1878-8769
          1878-8750
          June 2021
          : 150
          Affiliations
          [1 ] Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
          [2 ] Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India. Electronic address: kanwaljeet84@gmail.com.
          [3 ] Department of Anesthesia, Washington University in St. Louis, St. Louis, Missouri, USA.
          [4 ] Department of Neurological Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
          Article
          S1878-8750(21)00262-X
          10.1016/j.wneu.2021.02.069
          33631387
          2067f3aa-22af-4622-a190-06c0913953a1
          History

          Aneurysm,Cilostazol,Delayed cerebral ischemia,Mortality,Subarachnoid hemorrhage,Vasospasm

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