Inflammation and the depot-specific secretome of human preadipocytes.

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Abstract

Visceral white adipose tissue (WAT) expansion and macrophage accumulation are associated with metabolic dysfunction. Visceral WAT typically shows greater macrophage infiltration. Preadipocytes show varying proinflammatory expression profiles among WAT depots. The objective was to examine the secretomes and chemoattractive properties of preadipocytes from visceral and subcutaneous WAT.

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Author and article information

Journal

Journal ID (iso-abbrev): Obesity (Silver Spring)

Title: Obesity (Silver Spring, Md.)

Publisher: Wiley-Blackwell

ISSN (Electronic): 1930-739X

ISSN (Print): 1930-7381

Publication date (Electronic): May 2015

Volume: 23

Issue: 5

Affiliations

[1 ] Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA; Medical Genome Facility, Mayo Clinic, Rochester, Minnesota, USA.

Article

Mid ID: NIHMS660457

DOI: 10.1002/oby.21053

PMC ID: 4414793

PubMed ID: 25864718

SO-VID: 207455bf-4078-4e9a-9589-fc9fc28e919f

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