For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
10
views
48
references
 Top references
cited by
31
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      168
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      New entries toward the synthesis of OCF3-containing molecules

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The OCF 3 group is of high interest in the quest for new drugs and agrochemicals, thanks to its atypical features. This Highlight article depicted the recent and impressive advances toward the synthesis of OCF 3-containing molecules.

          Abstract

          The OCF 3 group is of high interest in the quest for new drugs and agrochemicals, thanks to its atypical features. This Highlight article depicts the recent and impressive advances toward the synthesis of OCF 3-containing molecules.

          Related collections

          Most cited references48

          • Record: found
          • Abstract: found
          • Article: not found

          Fluorine in medicinal chemistry.

          Sophie Purser, Peter R. Moore, Steve Swallow … (2008)
          It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
          Article 0 comments Cited 1167 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Catalysis for fluorination and trifluoromethylation.

            Takeru Furuya, Adam S. Kamlet, Tobias Ritter (2011)
            Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and practical fluorination reactions remain sought after. Fluorination of molecules often imparts desirable properties, such as metabolic and thermal stability, and fluorinated molecules are therefore frequently used as pharmaceuticals or materials. But the formation of carbon-fluorine bonds in complex molecules is a significant challenge. Here we discuss reactions to make organofluorides that have emerged within the past few years and which exemplify how to overcome some of the intricate challenges associated with fluorination.
            Article 0 comments Cited 447 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Introduction of fluorine and fluorine-containing functional groups.

              Theresa Liang, Constanze N. Neumann, Tobias Ritter (2013)
              Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation of the parent C-F bond, primarily as a consequence of the high hydration energy of fluoride, strong metal-fluorine bonds, and highly polarized bonds to fluorine. Most fluorination reactions still lack generality, predictability, and cost-efficiency. Despite all current limitations, modern fluorination methods have made fluorinated molecules more readily available than ever before and have begun to have an impact on research areas that do not require large amounts of material, such as drug discovery and positron emission tomography. This Review gives a brief summary of conventional fluorination reactions, including those reactions that introduce fluorinated functional groups, and focuses on modern developments in the field. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
              Article 0 comments Cited 395 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (publisher-id): OCFRA8
                Title: Organic Chemistry Frontiers
                Abbreviated Title: Org. Chem. Front.
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Electronic): 2052-4129
                Publication date Created: 2016
                Publication date (Electronic): 2016
                Volume: 3
                Issue: 8
                Pages: 1004-1010
                Affiliations
                [1 ]Normandie Univ.
                [2 ]COBRA
                [3 ]UMR 6014 et FR 3038
                [4 ]Univ. Rouen
                [5 ]INSA Rouen
                Article
                DOI: 10.1039/C6QO00164E
                SO-VID: 2127196f-0b98-475c-bb3f-6c391214c6bf
                Copyright © © 2016
                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content168

                See all similar

                Cited by27

                See all cited by

                Most referenced authors1,506

                See all reference authors