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      Possible prevention of neural-tube defects by periconceptional vitamin supplementation.

      Lancet
      Abortion, Spontaneous, epidemiology, Ascorbic Acid, administration & dosage, Avitaminosis, prevention & control, Clinical Trials as Topic, Drug Combinations, Female, Folic Acid, Follow-Up Studies, Humans, Infant, Newborn, Neural Tube Defects, Niacinamide, Pregnancy, Prospective Studies, Pyridoxine, Riboflavin, Thiamine, Vitamin A, Vitamin D, Vitamins

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          Abstract

          Women who had previously given birth to one or more infants with a neural-tube defect (NTD) were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants/fetuses of fully supplemented mothers (0.6%) had an NTD, compared with 13 of 260 infants/fetuses of unsupplemented mothers (5.0%).

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