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      Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease

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          Abstract

          Atherosclerotic cardiovascular disease (ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice (RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2019
          : 17
          : 1
          : 50-58
          Affiliations
          1 Department of Cardiology, The First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China
          2 Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China
          3 Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Drive NW, Calgary T2N 4N1, Canada
          4 Department of Cardiology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China
          5Class 2014, Medical College, University of South China, Hengyang 421001, China
          6Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China
          Author notes
          *Corresponding author: KUANG Ze-Min, E-mail: kuangzemin@ 123456outlook.com

          ΔThe first two authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30009-3
          10.1016/S1875-5364(19)30009-3
          30704624
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Clinical Vascular Grant In Chinese Physicians-VG
          Award ID: 2017-CCA-VG-016
          Funded by: Basic and Clinical Research Cooperation Project of Capital Medical University
          Award ID: 16JL42
          Funded by: Beijing Anzhen Hospital Affiliated with Capital Medical University
          Award ID: 2016P01
          This work was supported by Clinical Vascular Grant In Chinese Physicians-VG (No. 2017-CCA-VG-016), the Basic and Clinical Research Cooperation Project of Capital Medical University (No. 16JL42); the Presidential Foundation of Beijing Anzhen Hospital Affiliated with Capital Medical University (No. 2016P01).

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