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HLA-G: At the Interface of Maternal-Fetal Tolerance.

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      Abstract

      During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine mucosa without being rejected by the maternal immune system. Several mechanisms were initially proposed by Peter Medawar half a century ago to explain this apparent violation of the laws of transplantation. Then, three decades ago, an unusual human leukocyte antigen (HLA) molecule was identified: HLA-G. Uniquely expressed in EVT, HLA-G has since become the center of the present understanding of fetus-induced immune tolerance. Despite slow progress in the field, the last few years have seen an explosion in our knowledge of HLA-G biology. Here, we critically review new insights into the mechanisms controlling the expression and function of HLA-G at the maternal-fetal interface, and discuss their relevance for fetal tolerance.

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      Affiliations
      [1 ] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
      [2 ] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
      [3 ] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: jlstrom@fas.harvard.edu.
      Journal
      Trends Immunol.
      Trends in immunology
      Elsevier BV
      1471-4981
      1471-4906
      Apr 2017
      : 38
      : 4
      28279591
      S1471-4906(17)30023-6
      10.1016/j.it.2017.01.009

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