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      The endoplasmic reticulum stress response in immunity and autoimmunity.

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          Abstract

          Many exogenous sources of stress can lead to cell death. In recent years, endogenous cellular sources of stress have also been identified, including the stress that arises from the accumulation of unfolded proteins within a cell's endoplasmic reticulum (ER). To counterbalance this type of ER stress, higher eukaryotic cells possess a three-pronged signal-transduction pathway termed the unfolded-protein response (UPR). This Review focuses on the role of the UPR in the mammalian immune system and how manipulation of this complex signalling pathway may be of therapeutic benefit in human disease.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1733
          1474-1733
          Sep 2008
          : 8
          : 9
          Affiliations
          [1 ] Department of Infectious Diseases and Immunology, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115, USA.
          Article
          nri2359
          10.1038/nri2359
          18670423
          23644758-f3d5-4731-aedc-862eb117bf2e

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