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      Associação da Hipertensão com a Gravidade e a Mortalidade de Pacientes Hospitalizados com COVID-19 em Wuhan, China: Estudo Unicêntrico e Retrospectivo

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Resumo

          Fundamento

          A doença Coronavírus 2019 (COVID-19), causada pela síndrome respiratória aguda grave Coronavírus 2 (SARS-CoV-2), espalhou-se pelo mundo.

          Objetivo

          Investigar a associação entre a hipertensão e a gravidade/mortalidade de pacientes hospitalizados com COVID-19 em Wuhan, China.

          Métodos

          Um total de 337 pacientes diagnosticados com COVID-19 no Sétimo Hospital da cidade de Wuhan, de 20 de janeiro a 25 de fevereiro de 2020, foram inseridos e analisados em um estudo de caso unicêntrico e retrospectivo. O nível de significância adotado para a análise estatística foi 0,05.

          Resultados

          Dos 337 pacientes com diagnóstico confirmado de COVID-19, 297 (87.8%) tiveram alta do hospital e 40 pacientes (22,9%) morreram. A idade média foi de 58 anos (variando de 18 a 91 anos). Havia 112 (33,2%) pacientes diagnosticados com hipertensão no momento da internação (idade média, 65,0 anos [variação, 38-91 anos]; sendo 67 homens [59,8%, IC95%: 50,6%-69,0%], p=0,0209). Pacientes com hipertensão apresentaram uma porção significativamente maior de casos graves (69 [61,6%, IC95%: 52,5%-70,8%] vs. 117 [52,0%, IC95%: 45,4%-58,6%] em pacientes graves e 23 [19,3%, IC95%: 12,9%-28,1%] vs. 27 [12,0%, IC95%: 7,7%-16,3%] em pacientes críticos, p=0,0014) e maiores taxas de mortalidade (20 [17,9%, IC95%: 10,7%-25,1%] vs. 20 [8,9%, IC95%: 5,1%-12,6%, p=0,0202). Além disso, pacientes hipertensos apresentaram níveis anormais de vários indicadores, como linfopenia e inflamação, e nas funções cardíacas, hepáticas, renais e pulmonares no momento da internação. O grupo de pacientes com hipertensão também demonstrou níveis maiores de TNT e creatinina próximo da alta.

          Conclusão

          A hipertensão está altamente associada à gravidade ou mortalidade da COVID-19. Um tratamento agressivo deve ser considerado para pacientes hipertensos com COVID-19, principalmente com relação a lesões cardíacas e dos rins.

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          Most cited references29

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Wei-jie Guan, Zheng-yi Ni, Yu Hu … (2020)
          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            A Novel Coronavirus from Patients with Pneumonia in China, 2019

            Na Zhu, Dingyu Zhang, Wenling Wang … (2020)
            Summary In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)
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              Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

              Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
              In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
              Article 0 comments Cited 10853 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Arq Bras Cardiol
                Journal ID (iso-abbrev): Arq Bras Cardiol
                Journal ID (publisher-id): abc
                Title: Arquivos Brasileiros de Cardiologia
                Publisher: Sociedade Brasileira de Cardiologia - SBC
                ISSN (Print): 0066-782X
                ISSN (Electronic): 1678-4170
                Publication date (Electronic): 07 July 2021
                Publication date Collection: November 2021
                Volume: 117
                Issue: 5
                Pages: 911-921
                Affiliations
                [1 ] orgdiv2Department of Pediatrics orgdiv1Zhongnan Hospital orgnameWuhan University Wuhan China originalDepartment of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan - China
                [2 ] orgdiv2Department of Clinical Laboratory orgdiv1Zhongnan Hospital orgnameWuhan University Wuhan China originalDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan - China
                [3 ] orgdiv2Department of Urology orgdiv1Zhongnan Hospital orgnameWuhan University Wuhan China originalDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan - China
                [4 ] orgdiv2Institute of Medical Virology orgdiv1School of Basic Medical Sciences orgnameWuhan University Wuhan China originalState Key Laboratory of Virology/ Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan - China
                [1 ] China originalDepartment of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan - China
                [2 ] China originalDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University , Wuhan - China
                [3 ] China originalDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan - China
                [4 ] China originalState Key Laboratory of Virology/ Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan - China
                Author notes
                Correspondência: Xue-dong Fu e Hai-rong Xiong • Xue-dong Fu, MD, Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, 169 Donghu Road, Wuhan 430071, China E-mail: wb001865@ 123456whu.edu.cn , hrxiong@ 123456whu.edu.cn

                Contribuição dos autores

                Concepção e desenho da pesquisa e Revisão crítica do manuscrito quanto ao conteúdo intelectual importante: Hai-rong X, Xue-dong F; Obtenção de dados: You-ping D, Xie W, Liu T, Shou-yi W, Yu-xing Z, Xiao-bo M; Análise e interpretação dos dados: Xie W, Mei-rong W; Análise estatística: Yu-qing D; Redação do manuscrito: You-ping D, Hai-rong X.

                Potencial conflito de interesse

                Não há conflito com o presente artigo

                [*]

                Os autores contribuíram igualmente para este trabalho

                Mailing Address: Xue-dong Fu and Hai-rong Xiong • Xue-dong Fu, MD, Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, 169 Donghu Road, Wuhan 430071, China E-mail: wb001865@whu.edu.cn, hrxiong@whu.edu.cn

                Author Contributions

                Conception and design of the research and Critical revision of the manuscript for intellectual content: Hai-rong X, Xue-dong F; Acquisition of data: You-ping D, Xie W, Liu T, Shou-yi W, Yu-xing Z, Xiao-bo M; Analysis and interpretation of the data: Xie W, Mei-rong W; Statistical analysis: Yu-qing D; Writing of the manuscript: You-ping D, Hai-rong X.

                Potential Conflict of Interest

                No potential conflict of interest relevant to this article was reported.

                [*]

                Os autores contribuíram igualmente para este trabalho

                Author information
                https://orcid.org/0000-0002-4202-8218
                https://orcid.org/0000-0001-5056-2253
                https://orcid.org/0000-0003-1762-8526
                https://orcid.org/0000-0002-4028-0639
                Article
                Publisher ID: abc.20200733
                DOI: 10.36660/abc.20200733
                PMC ID: 8682108
                PubMed ID: 34287571
                SO-VID: 2367400d-6f22-47ab-8205-71b76b99c270
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 02 July 2020
                Date revision received : 28 October 2020
                Date accepted : 11 November 2020
                Page count
                Figures: 4, Tables: 8, Equations: 0, References: 23
                Categories
                Subject: Artigo Original

                Keywords: covid-19/complicações,betacoronavírus,síndrome respiratória aguda grave,hipertensão,comorbidades,fatores de risco
                Data availability:
                Keywords: covid-19/complicações, betacoronavírus, síndrome respiratória aguda grave, hipertensão, comorbidades, fatores de risco

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