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DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
A A Fienberg
1 ,
N Hiroi ,
P G Mermelstein ,
W Song ,
G L Snyder ,
A Nishi ,
A Cheramy ,
J P O'Callaghan ,
D B Miller ,
D G Cole ,
R Corbett ,
C N Haile ,
D C Cooper ,
S P Onn ,
A A Grace ,
C C Ouimet ,
F J White ,
S E Hyman ,
D J Surmeier ,
J Girault ,
E J Nestler ,
P Greengard
Aug 07 1998
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Abstract
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.