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      Efficacy and safety of laparoscopic vaginoplasty using the peritoneal flap and cervicoplasty in patients with congenital cervical and complete vaginal atresia: a pilot study

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          Abstract

          Background

          Hysterectomy places a huge physical and mental burden on young female patients with congenital cervical and complete vaginal atresia. Thus, it is necessary to develop a method to detach the obstruction and simultaneously preserve the vagina and uterus in these patients. This study sought to evaluate the efficacy and safety of laparoscopic vaginoplasty using the peritoneal flap and cervicoplasty in patients with congenital cervical and complete vaginal atresia.

          Methods

          Between April 2013 and June 2022, 9 patients with congenital cervical and complete vaginal atresia at Henan Provincial People’s Hospital were enrolled in this prospective study. All the patients were treated with laparoscopic vaginoplasty using the peritoneal flap and cervicoplasty. Baseline clinical features (such as age, uterus size, etc.) were collected. The surgical success rate and adverse events were assessed.

          Results

          The 9 enrolled patients had a median [interquartile range (IQR)] age of 15.0 (14.0–18.0) years, and 5/9 patients presented with pelvic adhesions. The surgeries were successful in all (9/9) patients, who preserved their vagina and uterus with a normal menstrual cycle. After a median follow-up duration of 48 months, the neovagina had a median length of 7.5 cm. Post-surgical complications occurred in 3/9 patients, which were cured by an appropriate treatment. The 5/9 married patients reported being satisfied with their sexual life.

          Conclusions

          Even though the current study preliminary exhibits the efficiency of laparoscopic vaginoplasty using the peritoneal flap and cervicoplasty in patients with congenital cervical and complete vaginal atresia, due to the small sample size, lack of a control group, and relatively high incidence of the adverse events, further studies are still needed to verify the current findings. The current study put forward a further direction for preserving the vagina and uterus simultaneously for those patients with congenital cervical and complete vaginal atresia.

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          Most cited references28

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          The ESHRE/ESGE consensus on the classification of female genital tract congenital anomalies.

          What classification system is more suitable for the accurate, clear, simple and related to the clinical management categorization of female genital anomalies?
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            The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, müllerian anomalies and intrauterine adhesions.

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              ACOG Committee Opinion No. 728: Müllerian Agenesis

              (2018)
              Müllerian agenesis, also referred to as müllerian aplasia, Mayer-Rokitansky-Küster-Hauser syndrome, or vaginal agenesis, has an incidence of 1 per 4,500-5,000 females. Müllerian agenesis is caused by embryologic underdevelopment of the müllerian duct, with resultant agenesis or atresia of the vagina, uterus, or both. Patients with müllerian agenesis usually are identified when they are evaluated for primary amenorrhea with otherwise typical growth and pubertal development. The most important steps in the effective management of müllerian agenesis are correct diagnosis of the underlying condition, evaluation for associated congenital anomalies, and psychosocial counseling in addition to treatment or intervention to address the functional effects of genital anomalies. The psychologic effect of the diagnosis of müllerian agenesis should not be underestimated. All patients with müllerian agenesis should be offered counseling and encouraged to connect with peer support groups. Future options for having children should be addressed with patients: options include adoption and gestational surrogacy. Assisted reproductive techniques with use of a gestational carrier (surrogate) have been shown to be successful for women with müllerian agenesis. Nonsurgical vaginal elongation by dilation should be the first-line approach. When well-counseled and emotionally prepared, almost all patients (90-96%) will be able to achieve anatomic and functional success by primary vaginal dilation. In cases in which surgical intervention is required, referrals to centers with expertise in this area should be considered because few surgeons have extensive experience in construction of the neovagina and surgery by a trained surgeon offers the best opportunity for a successful result.
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                Author and article information

                Journal
                Ann Transl Med
                Ann Transl Med
                ATM
                Annals of Translational Medicine
                AME Publishing Company
                2305-5839
                2305-5847
                23 February 2023
                31 March 2023
                : 11
                : 6
                : 257
                Affiliations
                [1 ]deptDepartment of Gynecology , Henan Provincial People’s Hospital , Zhengzhou, China;
                [2 ]deptDepartment of Gynecology , People’s Hospital of Zhengzhou University , Zhengzhou, China;
                [3 ]deptDepartment of Gynecology , People’s Hospital of Henan University , Zhengzhou, China
                Author notes

                Contributions: (I) Conception and design: Q Dang; (II) Administrative support: None; (III) Provision of study materials or patients: H Liu, H Zhang; (IV) Collection and assembly of data: C Wang; (V) Data analysis and interpretation: H Liu, H Zhang, C Wang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

                [#]

                These authors contributed equally to this work.

                Correspondence to: Qun Dang, MB. Department of Gynecology, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Zhengzhou 450000, China. Email: Dangjunyang@ 123456126.com .
                Article
                atm-11-06-257
                10.21037/atm-23-217
                10113076
                37082690
                23eea600-0f27-48ef-84f9-3c45f24572d6
                2023 Annals of Translational Medicine. All rights reserved.

                Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

                History
                : 27 December 2022
                : 15 February 2023
                Categories
                Original Article

                cervical atresia,cervicoplasty,complete vaginal atresia,laparoscopic surgery,vaginoplasty

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