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Small-airway obstruction and emphysema in chronic obstructive pulmonary disease.
John E McDonough
1 ,
Ren Yuan ,
Masaru Suzuki ,
Nazgol Seyednejad ,
W Mark Elliott ,
Pablo G Sanchez ,
Alexander C Wright ,
Warren B Gefter ,
Leslie Litzky ,
Harvey O Coxson ,
Peter D Paré ,
Don D Sin ,
Richard A Pierce ,
Jason C Woods ,
Annette M McWilliams ,
John R Mayo ,
Stephen C Lam ,
Joel D Cooper ,
James C Hogg
Oct 27 2011
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Abstract
The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm in diameter). We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD.