Investigation of an international outbreak of multidrug-resistant monophasic <i>Salmonella</i> Typhimurium associated with chocolate products, EU/EEA and United Kingdom, February to April 2022

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

An extensive multi-country outbreak of multidrug-resistant monophasic Salmonella Typhimurium infection in 10 countries with 150 reported cases, predominantly affecting young children, has been linked to chocolate products produced by a large multinational company. Extensive withdrawals and recalls of multiple product lines have been undertaken. With Easter approaching, widespread product distribution and the vulnerability of the affected population, early and effective real-time sharing of microbiological and epidemiological information has been of critical importance in effectively managing this serious food-borne incident.

Related collections

Most cited references 19

Record: found
Abstract: found
Article: found

Is Open Access

GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens

Zhemin Zhou, Nabil-Fareed Alikhan, Martin Sergeant … (2018)

Current methods struggle to reconstruct and visualize the genomic relationships of large numbers of bacterial genomes. GrapeTree facilitates the analyses of large numbers of allelic profiles by a static “GrapeTree Layout” algorithm that supports interactive visualizations of large trees within a web browser window. GrapeTree also implements a novel minimum spanning tree algorithm (MSTree V2) to reconstruct genetic relationships despite high levels of missing data. GrapeTree is a stand-alone package for investigating phylogenetic trees plus associated metadata and is also integrated into EnteroBase to facilitate cutting edge navigation of genomic relationships among bacterial pathogens.

0 comments Cited 327 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

The European Union One Health 2019 Zoonoses Report

(2021)

Abstract This report of the EFSA and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2019 in 36 European countries (28 Member States (MS) and eight non‐MS). The first and second most reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The EU trend for confirmed human cases of these two diseases was stable (flat) during 2015–2019. The proportion of human salmonellosis cases due to Salmonella Enteritidis acquired in the EU was similar to that in 2017–2018. Of the 26 MS reporting on Salmonella control programmes in poultry, 18 met the reduction targets, whereas eight failed to meet at least one. The EU prevalence of Salmonella target serovar‐positive flocks has been stable since 2015 for breeding hens, laying hens, broilers and fattening turkeys, with fluctuations for breeding turkey flocks. Salmonella results from competent authorities for pig carcases and for poultry tested through national control programmes were more frequently positive than those from food business operators. Shiga toxin‐producing Escherichia coli (STEC) infection was the third most reported zoonosis in humans and increased from 2015 to 2019. Yersiniosis was the fourth most reported zoonosis in humans in 2019 with a stable trend in 2015–2019. The EU trend of confirmed listeriosis cases remained stable in 2015–2019 after a long period of increase. Listeria rarely exceeded the EU food safety limit tested in ready‐to‐eat food. In total, 5,175 food‐borne outbreaks were reported. Salmonella remained the most detected agent but the number of outbreaks due to S. Enteritidis decreased. Norovirus in fish and fishery products was the agent/food pair causing the highest number of strong‐evidence outbreaks. The report provides further updates on bovine tuberculosis, Brucella, Trichinella, Echinococcus, Toxoplasma, rabies, West Nile virus, Coxiella burnetii (Q fever) and tularaemia.

0 comments Cited 275 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Salmonellosis outcomes differ substantially by serotype.

Timothy Jones, L Ingram, Paul R Cieslak … (2008)

Most human infections are caused by closely related serotypes within 1 species of Salmonella. Few data are available on differences in severity of disease among common serotypes. We examined data from all cases of Salmonella infection in FoodNet states during 1996-2006. Data included serotype, specimen source, hospitalization, and outcome. Among 46,639 cases, 687 serotypes were identified. Overall, 41,624 isolates (89%) were from stool specimens, 2524 (5%) were from blood, and 1669 (4%) were from urine; 10,393 (22%) cases required hospitalization, and death occurred in 219 (0.5%). The case fatality rate for S. Newport (0.3%) was significantly lower than for Typhimurium (0.6%); Dublin (3.0%) was higher. With respect to invasive disease, 13 serotypes had a significantly higher proportion than Typhimurium (6%), including Enteritidis (7%), Heidelberg (13%), Choleraesuis (57%), and Dublin (64%); 13 serotypes were significantly less likely to be invasive. Twelve serotypes, including Enteritidis (21%) and Javiana (21%), were less likely to cause hospitalization than Typhimurium (24%); Choleraesuis (60%) was significantly more so. Salmonella serotypes are closely related genetically yet differ significantly in their pathogenic potentials. Understanding the mechanisms responsible for this may be key to a more general understanding of the invasiveness of intestinal bacterial infections.

0 comments Cited 123 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Euro Surveill

Journal ID (iso-abbrev): Euro Surveill

Journal ID (publisher-id): eurosurveillance

Title: Eurosurveillance

Publisher: European Centre for Disease Prevention and Control (ECDC)

ISSN (Print): 1025-496X

ISSN (Electronic): 1560-7917

Publication date (Print): 14 April 2022

Volume: 27

Issue: 15

Electronic Location Identifier: 2200314

Affiliations

[1 ]Gastrointestinal Infections and Food Safety (One Health Unit), UK Health Security Agency, London, United Kingdom

[2 ]Institut Pasteur, Université Paris Cité, Centre National de Référence des E. coli, Shigella et Salmonella, Unité des Bactéries pathogènes entériques, Paris, France

[3 ]Sante Publique France, Direction des Maladies Infectieuses Unité EAZ, Paris, France

[4 ]Clinical and Protecting Health Directorate, Public Health Scotland, Glasgow, United Kingdom

[5 ]Robert Koch Institute, Department of Infectious Disease Epidemiology FG 35 - Gastrointestinal Infections, Zoonoses and Tropical Infections, Berlin, Germany

[6 ]Robert Koch Institute, Department of Infectious Diseases, Unit for Enteropathogenic Bacteria and Legionella / National Reference Centre for Salmonella and other Bacterial Enterics, Wernigerode, Germany

[7 ]Public Health Agency of Sweden, Unit for Zoonoses and Antibiotic Resistance, Stockholm, Sweden

[8 ]Public Health Agency of Sweden, Unit for laboratory surveillance of bacterial pathogens, Stockholm, Sweden

[9 ]Epidemiology of infectious diseases, Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium

[10 ]National Reference Centre for Salmonella and Shigella, Sciensano, Brussels, Belgium

[11 ]National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, Netherlands

[12 ]Health Inspection, Health Directorate, Luxembourg

[13 ]Laboratoire National de Santé, Epidemiology and Microbial Genomics, Dudelange, Luxembourg

[14 ]Department of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway

[15 ]HSE -Health Protection Surveillance Centre, Dublin, Ireland

[16 ]ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

[17 ]Instituto de Salud Carlos III. Centro Nacional de Microbiología, Madrid, Spain

[18 ]Instituto de Salud Carlos III. CIBER epidemiología y salud pública. Madrid, Spain

[19 ]Specialist Scientific Reference Service (Salmonella), Gastrointestinal Bacteria Reference Unit, UK Health Security Agency, London, United Kingdom

[20 ]Scottish Microbiology Reference Laboratories, Glasgow, United Kingdom

Author notes

Correspondence: Lesley Larkin ( Lesley.Larkin@ 123456phe.gov.uk )

Article

Publisher ID: 2200314 Publisher ID: 2200314

DOI: 10.2807/1560-7917.ES.2022.27.15.2200314

PMC ID: 9012091

PubMed ID: 35426359

SO-VID: 24544e41-d2e0-43ba-9953-366c8fb2ad03

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

History

Date received : 11 April 2022

Date accepted : 13 April 2022

Custom metadata

sequence 1

Keywords: monophasic salmonella typhimurium,outbreak,multi-country collaboration,chocolate products,descriptive epidemiological evidence,whole genome sequencing,core-genome multi locus sequence typing,antimicrobial resistance profile

Data availability:

Keywords: monophasic salmonella typhimurium, outbreak, multi-country collaboration, chocolate products, descriptive epidemiological evidence, whole genome sequencing, core-genome multi locus sequence typing, antimicrobial resistance profile

Investigation of an international outbreak of multidrug-resistant monophasic Salmonella Typhimurium associated with chocolate products, EU/EEA and United Kingdom, February to April 2022

Read this article at

Abstract

Related collections

Arabidopsis genomics

Most cited references 19

GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens

The European Union One Health 2019 Zoonoses Report

Salmonellosis outcomes differ substantially by serotype.

Author and article information

Journal

Affiliations

Author notes

Article

History

Categories

Custom metadata

Comments

Comment on this article

Similar content 146

Cited by 14

Most referenced authors 314