Preoperative chemoradiation therapy in combination with panitumumab for patients with resectable esophageal cancer: the PACT study.

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Abstract

Preoperative chemoradiation therapy (CRT) has become the standard treatment strategy for patients with resectable esophageal cancer. This multicenter phase 2 study investigated the efficacy of the addition of the epidermal growth factor receptor (EGFR) inhibitor panitumumab to a preoperative CRT regimen with carboplatin, paclitaxel, and radiation therapy in patients with resectable esophageal cancer.

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Journal

Journal ID (iso-abbrev): Int. J. Radiat. Oncol. Biol. Phys.

Title: International journal of radiation oncology, biology, physics

ISSN (Electronic): 1879-355X

ISSN (Print): 0360-3016

Publication date (Electronic): Sep 1 2014

Volume: 90

Issue: 1

Affiliations

[1 ] Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: s.kordes@amc.uva.nl.

[2 ] Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.

[3 ] Department of Radiotherapy, Academic Medical Center, Amsterdam, The Netherlands.

[4 ] Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands.

[5 ] Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

[6 ] Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

[7 ] Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands.

[8 ] Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

Article

Publisher Item ID: S0360-3016(14)00622-1

DOI: 10.1016/j.ijrobp.2014.05.022

PubMed ID: 25195993

SO-VID: 253f28fb-f920-4b59-9728-bc48090b6973

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