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      Interferon-gamma is produced by another player of innate immune responses: the interferon-producing killer dendritic cell (IKDC).

      Biochimie

      Animals, Antigens, CD45, metabolism, Antigens, Surface, Benzamides, Dendritic Cells, cytology, Humans, Interferon-gamma, biosynthesis, physiology, Interleukin-2, Killer Cells, Natural, Lectins, C-Type, Models, Biological, NK Cell Lectin-Like Receptor Subfamily B, Neoplasm Metastasis, Neoplasms, Piperazines, pharmacology, Proto-Oncogene Proteins c-kit, Pyrimidines, TNF-Related Apoptosis-Inducing Ligand

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          Abstract

          Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.

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          Journal
          17574720
          10.1016/j.biochi.2007.04.014

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