Effects of Post-Treatment with Direct Hemoperfusion Using a CTR Column on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats

Abstract

Background: To clarify the effects of post-treatment with direct hemoperfusion using a CTR column on the mortality and inflammatory responses to endotoxin-induced shock in rats. Methods: Thirty-six male rats were randomly assigned to 1 of 3 groups (n = 12/group): the endotoxemic group, receiving intravenous Escherichia coli endotoxin (15 mg/kg over 2 min); the control column group, treated without CTR for 120 min at 2 h after endotoxin injection, and CTR-post-treatment group, treated with CTR for 120 min at 2 h after endotoxin injection. Hemodynamics, arterial blood gases, and mortality were recorded for the 8-hour observation period, and plasma cytokine concentrations were measured every 4 h. Results: The mortality rates were 83, 83 and 33% for the endotoxemic, control column, and CTR post-treatment groups, respectively. The increases in IL-6 concentrations were less for the CTR post-treatment group than the other 2 groups. Conclusion: The present study shows that CTR post-treatment inhibited hypotension and elevations in IL-6 concentrations, reducing the mortality rate of rats with endotoxin-induced shock.

Journal

Journal ID (publisher-id): BPU

Journal ID (nlm-ta): Blood Purif

Journal ID (doi): 10.1159/issn.0253-5068

Title: Blood Purification

Publisher: S. Karger AG

ISSN (Print): 0253-5068

ISSN (Electronic): 1421-9735

Publication date Subscription-year: 2006

Publication date (Print): December 2006

Publication date (Electronic): 21 December 2006

Volume: 24

Issue: 5-6

Pages: 460-464

Affiliations

^aDepartment of Emergency and Critical Care Medicine, and ^bDepartment of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

Article

Publisher ID: 95554 Other ID: Blood Purif 2006;24:460–464

DOI: 10.1159/000095554

PubMed ID: 16953106

Copyright statement: © 2006 S. Karger AG, Basel

License:

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Page count

Figures: 3, Tables: 1, References: 10, Pages: 5

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Categories

Subject: Original Paper