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      Bioactive Peptides

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          Abstract

          The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

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          Most cited references178

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          Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

          Type 2 diabetes mellitus (T2DM) is a global pandemic, as evident from the global cartographic picture of diabetes by the International Diabetes Federation (http://www.diabetesatlas.org/). Diabetes mellitus is a chronic, progressive, incompletely understood metabolic condition chiefly characterized by hyperglycemia. Impaired insulin secretion, resistance to tissue actions of insulin, or a combination of both are thought to be the commonest reasons contributing to the pathophysiology of T2DM, a spectrum of disease originally arising from tissue insulin resistance and gradually progressing to a state characterized by complete loss of secretory activity of the beta cells of the pancreas. T2DM is a major contributor to the very large rise in the rate of non-communicable diseases affecting developed as well as developing nations. In this mini review, we endeavor to outline the current management principles, including the spectrum of medications that are currently used for pharmacologic management, for lowering the elevated blood glucose in T2DM.
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            Future directions for peptide therapeutics development.

            The notable expansion of peptide therapeutics development in the late 1990s and the 2000s led to an unprecedented number of marketing approvals in 2012 and has provided a robust pipeline that should deliver numerous approvals during the remainder of the 2010s. To document the current status of the pipeline, we collected data for peptide therapeutics in clinical studies and regulatory review, as well as those recently approved. In this Foundation review, we provide an overview of the pipeline, including therapeutic area and molecular targets, with a focus on glucagon-like peptide 1 receptor agonists. Areas for potential expansion, for example constrained peptides and peptide-drug conjugates, are profiled. Copyright © 2013 Elsevier Ltd. All rights reserved.
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              Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk.

              The inhibitory activity of angiotensin I-converting enzyme in milk increased during fermentation with the Calpis sour milk starter containing Lactobacillus helveticus and Saccharomyces cerevisiae. Two kinds of peptides inhibitory to angiotensin I-converting enzyme were purified from the sour milk by using four-step HPLC. The amino acid sequences of these inhibitors were identified as Val-Pro-Pro and Ile-Pro-Pro. The concentrations of peptides providing 50% inhibition of angiotensin I-converting enzyme were 9 and 5 microM, respectively. Most of the inhibitory activity in sour milk was attributed to these two peptides.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Foods
                Foods
                foods
                Foods
                MDPI
                2304-8158
                26 April 2017
                May 2017
                : 6
                : 5
                : 32
                Affiliations
                [1 ]Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea; ericdaliri@ 123456yahoo.com (E.B.-M.D.); deoghwa@ 123456kangwon.ac.kr (D.H.O.)
                [2 ]Department of Microbiology/Immunology, McGill University, Montreal, QC H3A 0G4, Canada
                Author notes
                [* ]Correspondence: byong.lee@ 123456mail.mcgill.ca ; Tel: +82-10-4779-9808
                Article
                foods-06-00032
                10.3390/foods6050032
                5447908
                28383504
                27c1512f-8f08-4957-af7f-0ee089dfce98
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 17 March 2017
                : 20 April 2017
                Categories
                Review

                functional foods,antihypertensive peptides,bioactivity,cytotoxicity

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