Blog
About

232
views
0
recommends
+1 Recommend
1 collections
    10
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive molecules with diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites from marine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representative cases are summarized focusing on molecular diversity, mining, and application of natural products from these marine organisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical molecules including their structures, chemical synthesis, bioactivities and mechanisms, structure–activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through the OSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactive natural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and their symbiotic fungi and bacteria.

          Related collections

          Author and article information

          Journal
          MLST
          Marine Life Science & Technology
          Springer (China )
          2096-6490
          2662-1746
          01 November 2019
          04 December 2019
          : 1
          : 1
          : 60-94
          Affiliations
          1Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
          2Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
          3Single-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China
          4Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China
          Author notes
          *Corresponding authors: Chang-Lun Shao, E-mail: shaochanglun@ 123456ouc.edu.cn , Chang-Yun Wang, changyun@ 123456ouc.edu.cn
          Article
          s42995-019-00021-2
          10.1007/s42995-019-00021-2
          © 2019 The Author(s)

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          Product
          Self URI (journal-page): https://www.springer.com/journal/42995
          Categories
          Review

          Comments

          Comment on this article