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      Can head sway patterns differentiate between patients with Meniere’s disease vs. peripheral vestibular hypofunction?

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          Abstract

          Background

          Meniere’s disease (MD) is defined by episodic vertigo, unilateral sensorineural hearing loss and fluctuating aural symptoms. Due to the variable clinical presentation, objective tests of MD may have significant diagnostic utility. Head kinematics derived from a head-mounted display (HMD) have demonstrated to be sensitive to vestibular dysfunction. The purpose of this pilot study was to investigate whether head sway can differentiate between patients with MD, vestibular hypofunction (VH) and healthy controls.

          Materials/methods

          80 adults (30 healthy controls, 32 with VH, and 18 with MD) were recruited from a tertiary vestibular clinic. All underwent a postural control assessment using the HTC Vive Pro Eye HMD that recorded head sway in the anterior–posterior (AP), medio-lateral (ML), pitch, yaw and roll direction. Participants were tested with 2 levels of visual load: a static versus oscillating star display. Each scene lasted 60 s and was repeated twice. Sway in each direction was quantified using root mean square velocity (VRMS) for the first 20 s and full 60 s of each scene.

          Results

          Static visual: participants with VH showed significantly larger head VRMS than controls in the AP (60 s and 20 s) and pitch (20 s) directions. Dynamic visual: participants with VH showed significantly larger head VRMS than controls all directions for both the 60 and 20 s analysis. Participants with MD did not differ significantly from the control or the VH group.

          Conclusion

          While limited in numbers, Patients with MD had a high variability in head sway in all directions, and their average head sway was between controls and those with VH. A larger sample as well as patients with worse symptoms at time of testing could elucidate whether head sway via HMD could become a viable test in this population. A similar finding between 20- and 60-s scene and the full portability of the system with an in-clinic testing setup could help these future endeavors. Head sway derived from HMD is sensitive to VH and can be clinically useful as an outcome measure to evaluate sensory integration for postural control.

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          Most cited references46

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          The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons

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            Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test.

            This study examined the sensitivity and specificity of the Timed Up & Go Test (TUG) under single-task versus dual-task conditions for identifying elderly individuals who are prone to falling. Fifteen older adults with no history of falls (mean age=78 years, SD=6, range=65-85) and 15 older adults with a history of 2 or more falls in the previous 6 months (mean age=86.2 years, SD=6, range=76-95) participated. Time taken to complete the TUG under 3 conditions (TUG, TUG with a subtraction task [TUGcognitive], and TUG while carrying a full cup of water [TUGmanual]) was measured. A multivariate analysis of variance and discriminant function and logistic regression analyses were performed. The TUG was found to be a sensitive (sensitivity=87%) and specific (specificity=87%) measure for identifying elderly individuals who are prone to falls. For both groups of older adults, simultaneous performance of an additional task increased the time taken to complete the TUG, with the greatest effect in the older adults with a history of falls. The TUG scores with or without an additional task (cognitive or manual) were equivalent with respect to identifying fallers and nonfallers. The results suggest that the TUG is a sensitive and specific measure for identifying community-dwelling adults who are at risk for falls. The ability to predict falls is not enhanced by adding a secondary task when performing the TUG.
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              The Development of the Dizziness Handicap Inventory

              Conventional vestibulometric techniques are inadequate for quantifying the impact of dizziness on everyday life. The 25-item Dizziness Handicap Inventory (DHI) was developed to evaluate the self-perceived handicapping effects imposed by vestibular system disease. The development of the preliminary (37 items) and final versions (25 items) of the DHI are described. The items were subgrouped into three content domains representing functional, emotional, and physical aspects of dizziness and unsteadiness. Cronbach's alpha coefficient was employed to measure reliability based on consistency of the preliminary version. The final version of the DHI was administered to 106 consecutive patients and demonstrated good internal consistency reliability. With the exception of the physical subscale, the mean values for DHI scale scores increased significantly with increases in the frequency of dizziness episodes. Test-retest reliability was high.
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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/1248354/overviewRole: Role: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/1341948/overviewRole: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/956330/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                Journal
                Front Neurol
                Front Neurol
                Front. Neurol.
                Frontiers in Neurology
                Frontiers Media S.A.
                1664-2295
                29 February 2024
                2024
                : 15
                : 1347335
                Affiliations
                [1] 1Ear Institute, New York Eye and Ear Infirmary of Mount Sinai , New York, NY, United States
                [2] 2Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai , New York, NY, United States
                [3] 3Department of Physical Therapy, Steinhardt School of Culture, Education and Human Development, New York University , New York, NY, United States
                Author notes

                Edited by: Dario Geisinger, Max Stern Academic College of Emek Yezreel, Israel

                Reviewed by: Ziv Yekutieli, Tel Aviv University, Israel

                Jennifer L. Millar, Johns Hopkins University, United States

                *Correspondence: Anat V. Lubetzky, anat@ 123456nyu.edu
                Article
                10.3389/fneur.2024.1347335
                10937734
                38487324
                28601efd-f15c-438f-84bd-a40d27d3f87a
                Copyright © 2024 Kelly, Cosetti and Lubetzky.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 30 November 2023
                : 19 February 2024
                Page count
                Figures: 6, Tables: 3, Equations: 0, References: 46, Pages: 11, Words: 6773
                Funding
                Funded by: National Institute on Deafness and Other Communication Disorders, doi 10.13039/100000055;
                Award ID: R21DC018101
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by an R21DC018101 Early Career Researcher grant from the National Institute on Deafness and Other Communication Disorders (NIDCD). The sponsors had no role in the study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
                Categories
                Neurology
                Original Research
                Custom metadata
                Neuro-Otology

                Neurology
                meniere’s disease,vestibular hypofunction,postural control,head kinematics,balance,vestibular disorders

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