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      Nanoemulsions: formation, properties and applications

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          Abstract

          Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes on the order of 100 nm.

          Abstract

          Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes on the order of 100 nm. Their small size leads to useful properties such as high surface area per unit volume, robust stability, optically transparent appearance, and tunable rheology. Nanoemulsions are finding application in diverse areas such as drug delivery, food, cosmetics, pharmaceuticals, and material synthesis. Additionally, they serve as model systems to understand nanoscale colloidal dispersions. High and low energy methods are used to prepare nanoemulsions, including high pressure homogenization, ultrasonication, phase inversion temperature and emulsion inversion point, as well as recently developed approaches such as bubble bursting method. In this review article, we summarize the major methods to prepare nanoemulsions, theories to predict droplet size, physical conditions and chemical additives which affect droplet stability, and recent applications.

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          The kinetics of precipitation from supersaturated solid solutions

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            Nanoemulsions versus microemulsions: terminology, differences, and similarities

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              Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity.

              Nanoemulsions fabricated from food-grade ingredients are being increasingly utilized in the food industry to encapsulate, protect, and deliver lipophilic functional components, such as biologically-active lipids (e.g., ω-3 fatty acids, conjugated linoleic acid) and oil-soluble flavors, vitamins, preservatives, and nutraceuticals. The small size of the particles in nanoemulsions (r<100 nm) means that they have a number of potential advantages over conventional emulsions-higher stability to droplet aggregation and gravitational separation, high optical clarity, ability to modulate product texture, and, increased bioavailability of lipophilic components. On the other hand, there may also be some risks associated with the oral ingestion of nanoemulsions, such as their ability to change the biological fate of bioactive components within the gastrointestinal tract and the potential toxicity of some of the components used in their fabrication. This review article provides an overview of the current status of nanoemulsion formulation, fabrication, properties, applications, biological fate, and potential toxicity with emphasis on systems suitable for utilization within the food and beverage industry. © Taylor and Francis Group, LLC
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                Author and article information

                Journal
                SMOABF
                Soft Matter
                Soft Matter
                Royal Society of Chemistry (RSC)
                1744-683X
                1744-6848
                2016
                2016
                : 12
                : 11
                : 2826-2841
                Affiliations
                [1 ]Massachusetts Institute of Technology
                [2 ]Cambridge, USA
                [3 ]Delft University of Technology
                [4 ]The Netherlands
                [5 ]Utrecht University
                Article
                10.1039/C5SM02958A
                26924445
                295e01fa-1e05-4fe0-aaea-0b01c7bbc70d
                © 2016
                History

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