Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma.

Santoni, Matteo; Piva, Francesco; De Giorgi, Ugo; Mosca, Alessandra; Basso, Umberto; Santini, Daniele; Buti, Sebastiano; Lolli, Cristian; Terrone, Carlo; Maruzzo, Marco; Iuliani, Michele; Bersanelli, Melissa; Conti, Alessandro; Mazzucchelli, Roberta; Montironi, Rodolfo; Burattini, Luciano; Berardi, Rossana

doi:10.21873/anticanres.12916

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Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma.

Author(s): Matteo Santoni ¹ , Francesco Piva ² , Ugo De Giorgi ³ , Alessandra Mosca ⁴ , Umberto Basso ⁵ , Daniele Santini ⁶ , Sebastiano Buti ⁷ , Cristian Lolli ³ , Carlo Terrone ⁸ , Marco Maruzzo ⁵ , Michele Iuliani ⁹ , Melissa Bersanelli ⁷ , Alessandro Conti ¹⁰ , Roberta Mazzucchelli ¹¹ , Rodolfo Montironi ¹¹ , Luciano Burattini ¹² , Rossana Berardi ¹²

Publication date (Electronic): October 2018

Journal: Anticancer research

Publisher: International Institute of Anticancer Research

Keywords: Autophagy, pazopanib, prognosis, progression-free survival, renal cell carcinoma, single nucleotide polymorphisms

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Abstract

Autophagy has been shown to be involved in cancer development and response to cancer therapy. In this study, genotypes of autophagic genes were analyzed to assess their correlation with the risk of clear cell renal cell carcinoma (ccRCC) and the outcome of patients treated with pazopanib for metastatic ccRCC.

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Journal ID (iso-abbrev): Anticancer Res.

Title: Anticancer research

Publisher: International Institute of Anticancer Research

ISSN (Electronic): 1791-7530

ISSN (Print): 0250-7005

Publication date (Electronic): October 2018

Volume: 38

Issue: 10

Affiliations

[1 ] Medical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi, G Salesi, Ancona, Italy mattymo@alice.it.

[2 ] Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy.

[3 ] Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS, Meldola, Italy.

[4 ] Medical Oncology, Maggiore della Carità University Hospital, University of Eastern Piedmont, Novara, Italy.

[5 ] Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV IRCCS, Padua, Italy.

[6 ] Medical Oncology, Campus Bio-Medico University of Rome, Rome, Italy.

[7 ] Oncology Unit, University Hospital of Parma, Parma, Italy.

[8 ] Division of Urology, San Martino Policlinic Hospital, University of Genoa, Genoa, Italy.

[9 ] Laboratory of Translational Oncology, Medical Oncology, Campus Bio-Medico University of Rome, Rome, Italy.

[10 ] Azienda Ospedaliera dell'Alto Adige, Bressanone/Brissen Hospital, Bressanone/Brissen, Italy.

[11 ] Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, Italy.

[12 ] Medical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi, G Salesi, Ancona, Italy.

Article

Publisher Item ID: 38/10/5773

DOI: 10.21873/anticanres.12916

PubMed ID: 30275199

SO-VID: 29cc8169-76c1-46b4-aea1-153c14de8f24

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Keywords: pazopanib,prognosis,progression-free survival,renal cell carcinoma,single nucleotide polymorphisms,Autophagy

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Keywords: pazopanib, prognosis, progression-free survival, renal cell carcinoma, single nucleotide polymorphisms, Autophagy

Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma.

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