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      Adrenergic and Serotoninergic Mechanisms in Human Hand Arteries and Veins Studied by Fluorescence Histochemistry and in vitro Pharmacology

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          Abstract

          Isolated hand arteries and veins from healthy human subjects were tested in vitro for their contractile response to adrenergic agonists and 5-hydroxytryptamine (5-HT) under standardized conditions. This allowed for quantitative estimation of various receptor characteristics. The relative sympathomimetic potency suggested α-adrenergic receptors, which was confirmed in Schild plots following phentolamine antagonism of the response (pA<sub>2</sub> for artery 7.57, for vein 7.75). 5-HT contracted with a relative potency approximately equal to noradrenaline and adrenaline in arteries, but only one fifth to one tenth of the catecholamine activity in veins. Ketanserin inhibited the 5-HT response in a competitive, probably also irreversible, manner in arteries (pA<sub>2</sub> 9.50, K<sub>A </sub>8.90 × 10<sup>–7</sup> M). In the veins, ketanserin counteracted the 5-HT-induced contraction in a noncompetitive way.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1985
          1985
          23 September 2008
          : 22
          : 1
          : 1-12
          Affiliations
          Departments of Surgery and Histology, University of Lund, Sweden
          Article
          158579 Blood Vessels 1985;22:1–12
          10.1159/000158579
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 12
          Categories
          Research Paper

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