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      Benefits of contrast-enhanced ultrasonography for interventional procedures

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          Abstract

          For evaluating unclear tumorous lesions, contrast-enhanced ultrasonography (CEUS) is an important imaging modality in addition to contrast-enhanced computed tomography and magnetic resonance imaging, and may provide valuable insights into the microvascularization of tumors in dynamic examinations. In interventional procedures, CEUS can make a valuable contribution in pre-, peri-, and post-interventional settings, reduce radiation exposure and, under certain circumstances, decrease the number of interventions needed for patients.

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          Most cited references56

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          The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version).

          The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.
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            How to perform Contrast-Enhanced Ultrasound (CEUS)

            “How to perform contrast-enhanced ultrasound (CEUS)” provides general advice on the use of ultrasound contrast agents (UCAs) for clinical decision-making and reviews technical parameters for optimal CEUS performance. CEUS techniques vary between centers, therefore, experts from EFSUMB, WFUMB and from the CEUS LI-RADS working group created a discussion forum to standardize the CEUS examination technique according to published evidence and best personal experience. The goal is to standardise the use and administration of UCAs to facilitate correct diagnoses and ultimately to improve the management and outcomes of patients.
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              The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations.

              The aim of the present retrospective study was to assess the incidence of adverse events (AE) of a second-generation ultrasound contrast agent in real clinical practice. A total of 28 Italian Centres provided data on the postmarketing use of SonoVue (Bracco Spa, Milan, Italy) in abdominal examination performed between December 2001 and December 2004. A total of 23 188 investigations were reported. No fatal event occurred. AEs were reported in 29 cases, of which only two were graded as serious; the rest, 27, were nonserious (23 mild, three moderate and one severe). The overall reporting rate of serious AE was 0.0086%. Overall, only four AEs required treatment (two serious, two nonserious including one moderate and one severe AEs). In conclusion, the present large-scale retrospective analysis showed that SonoVue has a good safety profile in abdominal applications, with an AE reporting rate lower than or similar to that reported for radiologic and magnetic resonance contrast agents.
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                Author and article information

                Journal
                Ultrasonography
                Ultrasonography
                USG
                Ultrasonography
                Korean Society of Ultrasound in Medicine
                2288-5919
                2288-5943
                April 2021
                19 November 2020
                : 40
                : 2
                : 207-216
                Affiliations
                [1 ]Department of Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, Germany
                [2 ]Institute of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Mannheim, Germany
                Author notes
                Correspondence to: Constantin Arndt Marschner, MD, Department of Radiology, University Hospital Munich, Ludwig-Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany Tel. +49-89-440073620 Fax. +49-89-440078832 E-mail: constantin.marschner@ 123456med.uni-muenchen.de
                Author information
                http://orcid.org/0000-0002-2042-7322
                http://orcid.org/0000-0003-0832-5662
                http://orcid.org/0000-0001-8501-2147
                http://orcid.org/0000-0003-3910-7801
                http://orcid.org/0000-0003-3889-5447
                Article
                usg-20083
                10.14366/usg.20083
                7994736
                33530676
                2bfa7bb4-6fea-48e7-879f-de30c825a822
                Copyright © 2021 Korean Society of Ultrasound in Medicine (KSUM)

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 3 June 2020
                : 17 November 2020
                : 19 November 2020
                Categories
                Review Article

                contrast-enhanced ultrasound,lesion,tissue vascularization,real-time imaging

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