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Semiconserved Regulation of Mesendoderm Differentiation by microRNAs
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Abstract
MicroRNAs are known to play important roles in many different processes. However,
their roles in shaping the early steps in embryogenesis have remained largely hidden.
In this issue of Developmental Cell, Rosa et al. show that the miR-430/427/302 family
of microRNAs has a distinct effect on Nodal signaling, affecting mesendoderm differentiation
in Xenopus embryos and human embryonic cell lines.