8
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      INFLUENCIA DE LOS FACTORES AMBIENTALES EN EL TEMPO DE LA PUBERTAD Translated title: INFLUENCE OF ENVIROMENTAL FACTORS IN THE TIMING OF PUBERTY

      other

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          En el tempo de la pubertad influyen factores genéticos y ambientales. Entre los últimos destacan por su frecuencia e importancia los factores nutricionales. Nos interesó actualizar sobre los factores que influyen en el tempo de la pubertad, con especial referencia a los factores ambientales y entre ellos los nutricionales, como la malnutrición por exceso y por déficit, los efectos de las enfermedades crónicas, la tendencia secular de la edad de inicio y progresión de la pubertad tanto en mujeres como en varones, el efecto de las migraciones y de la desnutrición intrauterina sobre la programación. Además se mencionan factores como los disruptores ambientales, el efecto del clima, de la luz y de la oscuridad. Se enfatiza la importancia de un ambiente propicio para una adecuada expresión del potencial genético

          Translated abstract

          Genetic and environmental factors influence the timing of puberty. Nutritional factors are very important due to their frequency and importance. We review here the factors that influence the timing of puberty, with special reference to nutrition, one of the environmental factors. Overweight and malnutrition aspects, the effect of chronic illnesses, the trends in the age of beginning and progression of puberty of girls and boys, the effect of migration and of intrauterine malnutrition over programming are discussed. Also the effect of environmental disruptors on puberty like the weather, light and darkness are mentioned. The importance of a proper environment for an adequate expression of genetic potential is reinforced

          Related collections

          Most cited references89

          • Record: found
          • Abstract: not found
          • Article: not found

          Variations in the Pattern of Pubertal Changes in Boys

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

            The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure. Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family. In rodents, homozygous mutations in genes encoding leptin or the leptin receptor cause early-onset morbid obesity, hyperphagia and reduced energy expenditure. These rodents also show hypercortisolaemia, alterations in glucose homeostasis, dyslipidaemia, and infertility due to hypogonadotropic hypogonadisms. In humans, leptin deficiency due to a mutation in the leptin gene is associated with early-onset obesity. Here we describe a homozygous mutation in the human leptin receptor gene that results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains. In addition to their early-onset morbid obesity, patients homozygous for this mutation have no pubertal development and their secretion of growth hormone and thyrotropin is reduced. These results indicate that leptin is an important physiological regulator of several endocrine functions in humans.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

              We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur. In the present study, we investigate the possible central mode of action of GPR54 and kisspeptin ligand. First, we show that GPR54 transcripts are colocalized with gonadotropin-releasing hormone (GnRH) neurons in the mouse hypothalamus, suggesting that kisspeptin, the GPR54 ligand, may act directly on these neurons. Next, we show that GnRH neurons seem anatomically normal in gpr54-/- mice, and that they show projections to the median eminence, which demonstrates that the hypogonadism in gpr54-/- mice is not due to an abnormal migration of GnRH neurons (as occurs with KAL1 mutations), but that it is more likely due to a lack of GnRH release or absence of GnRH neuron stimulation. We also show that levels of kisspeptin injected i.p., which stimulate robust LH and FSH release in wild-type mice, have no effect in gpr54-/- mice, and therefore that kisspeptin acts directly and uniquely by means of GPR54 signaling for this function. Finally, we demonstrate by direct measurement, that the central administration of kisspeptin intracerebroventricularly in sheep produces a dramatic release of GnRH into the cerebrospinal fluid, with a parallel rise in serum LH, demonstrating that a key action of kisspeptin on the hypothalamo-pituitary-gonadal axis occurs directly at the level of GnRH release. The localization and GnRH release effects of kisspeptin thus define GPR54 as a major control point in the reproductive axis and suggest kisspeptin to be a neurohormonal effector.
                Bookmark

                Author and article information

                Journal
                rchnut
                Revista chilena de nutrición
                Rev. chil. nutr.
                Sociedad Chilena de Nutrición, Bromatología y Toxicología (Santiago, , Chile )
                0717-7518
                June 2007
                : 34
                : 2
                : 96-104
                Affiliations
                [01] orgnameUniversidad de Chile orgdiv1Instituto de Nutrición y Tecnología de los Alimentos orgdiv2Unidad de Micronutrientes Chile smuzzo@ 123456inta.cl
                Article
                S0717-75182007000200001 S0717-7518(07)03400200001
                10.4067/S0717-75182007000200001
                2ed5794a-01ca-4d22-abd4-a700b82b9e9f

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 19 January 2007
                : 14 May 2007
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 57, Pages: 9
                Product

                SciELO Chile

                Categories
                ARTICULOS DE ACTUALIZACION

                nutrition,genetic and environmental factors,Timing of puberty,nutrición,factores genéticos y ambientales,tempo de la pubertad

                Comments

                Comment on this article