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      Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

      Neurology
      Adult, Atrophy, genetics, pathology, physiopathology, Brain Mapping, Cerebral Cortex, Cognition Disorders, psychology, Corpus Striatum, DNA Mutational Analysis, Female, Genetic Testing, Genotype, Humans, Huntington Disease, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Tissue Proteins, Neuropsychological Tests, Nuclear Proteins, Trinucleotide Repeats

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          Abstract

          The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

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