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      On the attribution and additivity of binding energies.

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          Abstract

          It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A-B, and of its component parts, A and B, in terms of the "intrinsic binding energies" of A and B, DeltaG(A) (i) and DeltaG(B) (i), and a "connection Gibbs energy," DeltaG(s) that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed DeltaH and TDeltaS values for aqueous solutions. The DeltaG(i) and DeltaG(s) terms can be large for binding to enzymes and other proteins.

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          Author and article information

          Journal
          Proc Natl Acad Sci U S A
          Proceedings of the National Academy of Sciences of the United States of America
          Proceedings of the National Academy of Sciences
          0027-8424
          0027-8424
          Jul 1981
          : 78
          : 7
          Affiliations
          [1 ] Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254.
          Article
          10.1073/pnas.78.7.4046
          319722
          16593049
          2f1f8478-6256-41bb-99e6-7c8241e67c0c
          History

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