Kylie M. Quinn: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: ValidationRole:
Writing – review & editing
Wan-Ting Kan: Role: Formal analysisRole: InvestigationRole: Validation
Katherine A. Watson: Role: Formal analysisRole: InvestigationRole: Validation
Brian J. Liddicoat: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Natasha G. Swan: Role: Formal analysisRole: InvestigationRole: ValidationRole: Writing – review & editing
Hayley McQuilten: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Alice E. Denton: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Jasmine Li: Role: ConceptualizationRole: Writing – review & editing
Weisan Chen: Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: Writing – review
& editing
Lorena E. Brown: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
David C. Jackson: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Patrick C. Reading: Role: ConceptualizationRole: ResourcesRole: Writing – review & editing
Peter C. Doherty: Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: Supervision
Katherine Kedzierska: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Lukasz Kedzierski: Role: Writing – original draftRole: Writing – review & editing
Stephen J. Turner: Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: Writing – review & editing
Nicole L. La Gruta:
ORCID: http://orcid.org/0000-0001-5358-9363
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing – original draftRole: Writing – review & editing
Jie Sun: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
September
2017
Publication date Collection: 2017
Volume: 12
Issue: 9
Electronic Location Identifier: e0184732
Affiliations
[1
]
Infection and Immunity Program and Department of Biochemistry and Molecular Biology,
Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia
[2
]
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and
Immunity, University of Melbourne, Parkville, Victoria, Australia
[3
]
T cell laboratory, School of Molecular Sciences, La Trobe University, Bundoora, Victoria,
Australia
[4
]
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, United
States of America
[5
]
Faculty of Veterinary and Agricultural Sciences, Peter Doherty Institute for Infection
and Immunity, University of Melbourne, Parkville, Victoria, Australia
Mayo Clinic Minnesota, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
[¤a]
Current address: The Walter and Eliza Hall Institute, Parkville, Victoria, Australia
[¤b]
Current address: Broad Institute of MIT and Harvard, Cambridge, MA, United States
of America
[¤c]
Current address: Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
Author information
Article
Publisher ID:
PONE-D-17-18933
DOI: 10.1371/journal.pone.0184732
PMC ID: 5590991
PubMed ID: 28886201
SO-VID: 2fd1258b-17d8-4ff3-8448-b096e90d4719
Copyright © © 2017 Quinn et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-5358-9363
Nicole L. La Gruta
Funded by: funder-id http://dx.doi.org/10.13039/100008717, Sylvia and Charles Viertel Charitable Foundation;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-5358-9363
Nicole L. La Gruta
This work was supported by Australian National Health and Medical Research Council
(NHMRC) funding (APP1071916). and a Sylvia and Charles Viertel Senior Medical Research
Fellowship awarded to N.L.L.G.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen
Subject:
Research and Analysis Methods
Subject:
Specimen Preparation and Treatment
Subject:
Staining
Subject:
Cell Staining
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response