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      Galectins as modulators of tumour progression.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, by interacting with cytoplasmic and nuclear proteins to modulate signalling pathways. Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis. They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology?

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Jan 2005
          : 5
          : 1
          Affiliations
          [1 ] Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA. fliu@ucdavis.edu
          Article
          nrc1527
          10.1038/nrc1527
          15630413
          3149623b-54db-4f3e-85e2-b5a454c52f64
          History

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