Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

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Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

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Author and article information

Journal

Journal ID (iso-abbrev): Cell

Title: Cell

Publisher: Elsevier BV

ISSN (Electronic): 1097-4172

ISSN (Print): 0092-8674

Publication date (Electronic): Jun 01 2017

Volume: 169

Issue: 6

Affiliations

[1 ] Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rnusse@stanford.edu.

[2 ] Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

Article

Publisher Item ID: S0092-8674(17)30547-0

DOI: 10.1016/j.cell.2017.05.016

PubMed ID: 28575679

SO-VID: 321b1122-487c-4f03-a2a1-f135c6da322e

History

Keywords: Wnt,cancer,development,stem cells,therapy

Data availability:

Keywords: Wnt, cancer, development, stem cells, therapy

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