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      Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

      Cell
      Elsevier BV
      Wnt, cancer, development, stem cells, therapy

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          Abstract

          The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

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          Author and article information

          Journal
          28575679
          10.1016/j.cell.2017.05.016

          Wnt,cancer,development,stem cells,therapy
          Wnt, cancer, development, stem cells, therapy

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