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      Automatic detection of actionable radiology reports using bidirectional encoder representations from transformers

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          Abstract

          Background

          It is essential for radiologists to communicate actionable findings to the referring clinicians reliably. Natural language processing (NLP) has been shown to help identify free-text radiology reports including actionable findings. However, the application of recent deep learning techniques to radiology reports, which can improve the detection performance, has not been thoroughly examined. Moreover, free-text that clinicians input in the ordering form (order information) has seldom been used to identify actionable reports. This study aims to evaluate the benefits of two new approaches: (1) bidirectional encoder representations from transformers (BERT), a recent deep learning architecture in NLP, and (2) using order information in addition to radiology reports.

          Methods

          We performed a binary classification to distinguish actionable reports (i.e., radiology reports tagged as actionable in actual radiological practice) from non-actionable ones (those without an actionable tag). 90,923 Japanese radiology reports in our hospital were used, of which 788 (0.87%) were actionable. We evaluated four methods, statistical machine learning with logistic regression (LR) and with gradient boosting decision tree (GBDT), and deep learning with a bidirectional long short-term memory (LSTM) model and a publicly available Japanese BERT model. Each method was used with two different inputs, radiology reports alone and pairs of order information and radiology reports. Thus, eight experiments were conducted to examine the performance.

          Results

          Without order information, BERT achieved the highest area under the precision-recall curve (AUPRC) of 0.5138, which showed a statistically significant improvement over LR, GBDT, and LSTM, and the highest area under the receiver operating characteristic curve (AUROC) of 0.9516. Simply coupling the order information with the radiology reports slightly increased the AUPRC of BERT but did not lead to a statistically significant improvement. This may be due to the complexity of clinical decisions made by radiologists.

          Conclusions

          BERT was assumed to be useful to detect actionable reports. More sophisticated methods are required to use order information effectively.

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          Most cited references37

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          Long Short-Term Memory

          Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.
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            Regularization Paths for Generalized Linear Models via Coordinate Descent

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              An introduction to ROC analysis

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                Author and article information

                Contributors
                yutanakamura-tky@umin.ac.jp
                hanaoka-tky@umin.ac.jp
                nomuray-tky@umin.ac.jp
                tanakao-tky@umin.ac.jp
                smiki-tky@umin.ac.jp
                watadat-tky@umin.ac.jp
                takeharu-yoshikawa@umin.ac.jp
                naoto-tky@umin.ac.jp
                abediag-tky@umin.ac.jp
                Journal
                BMC Med Inform Decis Mak
                BMC Med Inform Decis Mak
                BMC Medical Informatics and Decision Making
                BioMed Central (London )
                1472-6947
                11 September 2021
                11 September 2021
                2021
                : 21
                : 262
                Affiliations
                [1 ]GRID grid.26999.3d, ISNI 0000 0001 2151 536X, Division of Radiology and Biomedical Engineering, Graduate School of Medicine, , The University of Tokyo, ; 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan
                [2 ]GRID grid.412708.8, ISNI 0000 0004 1764 7572, The Department of Radiology, , The University of Tokyo Hospital, ; 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan
                [3 ]GRID grid.412708.8, ISNI 0000 0004 1764 7572, The Department of Computational Diagnostic Radiology and Preventive Medicine, , The University of Tokyo Hospital, ; 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan
                Article
                1623
                10.1186/s12911-021-01623-6
                8436473
                34511100
                33168c0c-966e-4405-bddc-11184c75dbc7
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 17 February 2021
                : 23 August 2021
                Categories
                Research
                Custom metadata
                © The Author(s) 2021

                Bioinformatics & Computational biology
                radiology reports,actionable finding,natural language processing (nlp),bidirectional encoder representations from transformers (bert),deep learning

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