For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
Inviting an author to review:
Microneedle-Mediated Transdermal Delivery of Drug-Carrying Nanoparticles
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
9
views
39
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      592
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The long noncoding RNA DARS-AS1 was aberrantly expressed and participated in several human cancer progressions, whereas whether DARS-AS1 is involved in human gastric cancer remains unclear. This study aimed to investigate the influence of DARS-AS1 on gastric cancer progression and explore the potential regulatory network of DARS-AS1/miR-330-3p/NAT10. The expression levels of DARS-AS1, miR-330-3p, and NAT10 were measured by quantitative real-time polymerase chain reaction. The CCK-8 assay and Transwell assay were used to determine the cell viability, migration, and invasion capacities, respectively. The target association between miR-330-3p and DARS-AS1 or NAT10 was confirmed using a luciferase reporter assay. In result, DARS-AS1 levels were elevated in tumor tissues and associated with shorter overall survival in patients with gastric cancer. Knockdown of DARS-AS1 could hamper cell viability, migration, and invasion in gastric cancer cells. DARS-AS1 acts as a competitive endogenous RNA to regulate the NAT10 expression by sponging miR-330-3p in gastric cancer cells. In conclusion, DARS-AS1 was elevated in gastric cancer, and DARS-AS1/miR-330-3p/NAT10 signaling offered some new horizons for predicting prognosis and a novel therapeutic method for the treatment of gastric cancer.

          Related collections

          Most cited references39

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

          Jun-Hao Li, Shun Liu, Hui Zhou … (2013)
          Although microRNAs (miRNAs), other non-coding RNAs (ncRNAs) (e.g. lncRNAs, pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been implicated in cell-fate determination and in various human diseases, surprisingly little is known about the regulatory interaction networks among the multiple classes of RNAs. In this study, we developed starBase v2.0 (http://starbase.sysu.edu.cn/) to systematically identify the RNA–RNA and protein–RNA interaction networks from 108 CLIP-Seq (PAR-CLIP, HITS-CLIP, iCLIP, CLASH) data sets generated by 37 independent studies. By analyzing millions of RNA-binding protein binding sites, we identified ∼9000 miRNA-circRNA, 16 000 miRNA-pseudogene and 285 000 protein–RNA regulatory relationships. Moreover, starBase v2.0 has been updated to provide the most comprehensive CLIP-Seq experimentally supported miRNA-mRNA and miRNA-lncRNA interaction networks to date. We identified ∼10 000 ceRNA pairs from CLIP-supported miRNA target sites. By combining 13 functional genomic annotations, we developed miRFunction and ceRNAFunction web servers to predict the function of miRNAs and other ncRNAs from the miRNA-mediated regulatory networks. Finally, we developed interactive web implementations to provide visualization, analysis and downloading of the aforementioned large-scale data sets. This study will greatly expand our understanding of ncRNA functions and their coordinated regulatory networks.
          Article 0 comments Cited 1747 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Long Noncoding RNA and Cancer: A New Paradigm.

            Milad Soleimani, Subhrangsu Mandal, Arunoday Bhan (2017)
            In addition to mutations or aberrant expression in the protein-coding genes, mutations and misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in cancer. Genome-wide association studies of tumor samples have identified a large number of lncRNAs associated with various types of cancer. Alterations in lncRNA expression and their mutations promote tumorigenesis and metastasis. LncRNAs may exhibit tumor-suppressive and -promoting (oncogenic) functions. Because of their genome-wide expression patterns in a variety of tissues and their tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and therapeutic targets for cancer. In this article, we have reviewed the emerging functions and association of lncRNAs in different types of cancer and discussed their potential implications in cancer diagnosis and therapy. Cancer Res; 77(15); 3965-81. ©2017 AACR.
            Article 0 comments Cited 1053 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              LncRNA-mediated regulation of cell signaling in cancer

              Wan-Xin Peng, Pratirodh Koirala, Yin-Yuan Mo (2017)
              To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA-protein or protein-protein complexes, in this review we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.
              Article 0 comments Cited 689 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Weibo Wang
                Journal
                Journal ID (nlm-ta): Open Med (Wars)
                Journal ID (iso-abbrev): Open Med (Wars)
                Journal ID (publisher-id): med
                Title: Open Medicine
                Publisher: De Gruyter
                ISSN (Electronic): 2391-5463
                Publication date (Electronic): 13 December 2022
                Publication date Collection: 2022
                Volume: 17
                Issue: 1
                Pages: 2036-2045
                Affiliations
                Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, Shandong, 250021, China
                Department of Oncology, Binzhou Medical University Hospital , Binzhou, Shandong, 256603, China
                Department of Pediatrics, Binzhou Medical University Hospital , Binzhou, Shandong, 256603, China
                Department of Breast Surgery, Binzhou Medical University Hospital , Binzhou, Shandong, 256603, China
                Department of Health Management, Binzhou Medical University Hospital , Binzhou, Shandong, 256603, China
                Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University , No 324, Jingwuweiqi Road, Jinan, Shandong, 250021, China
                Author notes

                # Chunjuan Du and Xia Han, contributed equally to this work.

                Article
                Publisher ID: med-2022-0583
                DOI: 10.1515/med-2022-0583
                PMC ID: 9755708
                PubMed ID: 36568518
                SO-VID: 331fe08b-3b64-42ec-a208-0c87ba12e8a9
                Copyright © © 2022 the author(s), published by De Gruyter
                License:

                This work is licensed under the Creative Commons Attribution 4.0 International License.

                History
                Date received : 01 April 2022
                Date revision received : 01 August 2022
                Date accepted : 18 September 2022
                Page count
                Pages: 10
                Categories
                Subject: Research Article

                Keywords: gastric cancer,dars-as1,nat10,mir-330-3p,progression
                Data availability:
                Keywords: gastric cancer, dars-as1, nat10, mir-330-3p, progression

                Comments

                Comment on this article

                scite_

                Similar content592

                See all similar

                Cited by1

                See all cited by

                Most referenced authors428

                See all reference authors