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      The current and future global distribution and population at risk of dengue

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          Abstract

          Dengue is a mosquito-borne viral infection that has spread throughout the tropical world over the past 60 years and now affects over half the world’s population. The geographical range of dengue is expected to further expand due to ongoing global phenomena including climate change and urbanization. We applied statistical mapping techniques to the most extensive database of case locations to date to predict global environmental suitability for the virus as of 2015. We then made use of climate, population and socioeconomic projections for the years 2020, 2050 and 2080 to project future changes in virus suitability and human population at risk. This study is the first to consider the spread of Aedes mosquito vectors to project dengue suitability. Our projections provide a key missing piece of evidence for the changing global threat of vector-borne disease and will help decision-makers worldwide to better prepare for and respond to future changes in dengue risk.

          Abstract

          Statistical mapping techniques provide insights into the current geographical spread of the mosquito-borne dengue virus infection and predict changes in the areas that will be environmentally suitable to the virus for the years 2020, 2050 and 2080.

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          RCP 8.5—A scenario of comparatively high greenhouse gas emissions

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            A new scenario framework for climate change research: the concept of shared socioeconomic pathways

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              Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century

              Dengue is the most important arboviral disease of humans with over half of the world’s population living in areas of risk. The frequency and magnitude of epidemic dengue have increased dramatically in the past 40 years as the viruses and the mosquito vectors have both expanded geographically in the tropical regions of the world. There are many factors that have contributed to this emergence of epidemic dengue, but only three have been the principal drivers: 1) urbanization, 2) globalization and 3) lack of effective mosquito control. The dengue viruses have fully adapted to a human-Aedes aegypti-human transmission cycle, in the large urban centers of the tropics, where crowded human populations live in intimate association with equally large mosquito populations. This setting provides the ideal home for maintenance of the viruses and the periodic generation of epidemic strains. These cities all have modern airports through which 10s of millions of passengers pass each year, providing the ideal mechanism for transportation of viruses to new cities, regions and continents where there is little or no effective mosquito control. The result is epidemic dengue. This paper discusses this unholy trinity of drivers, along with disease burden, prevention and control and prospects for the future.
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                Author and article information

                Contributors
                jane.messina@ouce.ox.ac.uk
                sihay@uw.edu
                Journal
                Nat Microbiol
                Nat Microbiol
                Nature Microbiology
                Nature Publishing Group UK (London )
                2058-5276
                10 June 2019
                10 June 2019
                2019
                : 4
                : 9
                : 1508-1515
                Affiliations
                [1 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, School of Geography and the Environment, , University of Oxford, ; Oxford, UK
                [2 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, School of Interdisciplinary Area Studies, , University of Oxford, ; Oxford, UK
                [3 ]ISNI 0000 0004 0425 469X, GRID grid.8991.9, Centre for the Mathematical Modelling of Infectious Diseases, , London School of Hygiene & Tropical Medicine, ; London, UK
                [4 ]ISNI 0000 0004 0425 469X, GRID grid.8991.9, Department of Infectious Disease Epidemiology, , London School of Hygiene & Tropical Medicine, ; London, UK
                [5 ]ISNI 0000 0001 2179 088X, GRID grid.1008.9, School of BioSciences, , University of Melbourne, ; Parkville, VIC Australia
                [6 ]ISNI 000000041936754X, GRID grid.38142.3c, Harvard Medical School, , Harvard University, ; Boston, MA USA
                [7 ]ISNI 0000 0004 0378 8438, GRID grid.2515.3, Boston Children’s Hospital, ; Boston, MA USA
                [8 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, Department of Zoology, , University of Oxford, ; Oxford, UK
                [9 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, Environmental Research Group Oxford, c/o Department of Zoology, , University of Oxford, ; Oxford, UK
                [10 ]ISNI 0000000122986657, GRID grid.34477.33, Institute for Health Metrics and Evaluation, University of Washington, ; Seattle, WA USA
                [11 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, , University of Oxford, ; Oxford, UK
                [12 ]ISNI 0000 0001 2348 0746, GRID grid.4989.c, Université Libre de Bruxelles, ; Brussels, Belgium
                [13 ]ISNI 0000000121633745, GRID grid.3575.4, World Health Organization, ; Geneva, Switzerland
                [14 ]Waen Associates Ltd, Y Waen, Islaw’r Dref, Dolgellau, Gwynedd, UK
                [15 ]ISNI 0000 0001 0328 4908, GRID grid.5253.1, Department of Infectious Diseases, Section Clinical Tropical Medicine, , Heidelberg University Hospital, ; Heidelberg, Germany
                [16 ]ISNI 0000 0004 1936 9684, GRID grid.27860.3b, Department of Entomology and Nematology, , University of California, ; Davis, USA
                Author information
                http://orcid.org/0000-0001-7829-1272
                http://orcid.org/0000-0001-8916-5570
                http://orcid.org/0000-0001-8838-7147
                http://orcid.org/0000-0002-7205-9621
                http://orcid.org/0000-0002-0611-7272
                Article
                476
                10.1038/s41564-019-0476-8
                6784886
                31182801
                334aab19-2747-4d65-9258-e53672910aad
                © The Author(s), under exclusive licence to Springer Nature Limited 2019

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 20 December 2018
                : 1 May 2019
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                © The Author(s), under exclusive licence to Springer Nature Limited 2019

                infectious diseases,diseases
                infectious diseases, diseases

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