Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

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Abstract

We report a genome-wide association study (GWAS) of two populations, African-American and European-American (AA, EA) for opioid dependence (OD) in three sets of subjects, to identify pathways, genes, and alleles important in OD risk.

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Journal ID (iso-abbrev): Biol. Psychiatry

Title: Biological psychiatry

ISSN (Electronic): 1873-2402

ISSN (Print): 0006-3223

Publication date (Electronic): Jul 1 2014

Volume: 76

Issue: 1

Affiliations

[1 ] Department of Psychiatry, Division of Human Genetics, Departments of Genetics and Neurobiology, Yale University School of Medicine, VA Connecticut Healthcare Center, West Haven. Electronic address: joel.gelernter@yale.edu.

[2 ] Philadelphia VA Medical Center, Philadelphia, Pennsylvania.

[3 ] Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.

[4 ] University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

[5 ] Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas.

[6 ] Departments Biostatistics and Genetics, Yale School of Public Health, Yale University, New Haven, CT.

[7 ] Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts; Departments of Neurology, Ophthalmology, Genetics and Genomics, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts.

Article

Publisher Item ID: S0006-3223(13)00826-3 Mid ID: NIHMS525621

DOI: 10.1016/j.biopsych.2013.08.034

PubMed ID: 24143882

SO-VID: 342aab12-cc5c-49a5-a349-4c70698a4697

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Keywords: Calcium signaling,complex traits,convergence,genome-wide association,opioid dependence,potassium

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Keywords: Calcium signaling, complex traits, convergence, genome-wide association, opioid dependence, potassium

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

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