Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson's disease revealed by deep sequencing analysis.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Most computational tools for small non-coding RNAs (sRNA) sequencing data analysis focus in microRNAs (miRNAs), overlooking other types of sRNAs that show multi-mapping hits. Here, we have developed a pipeline to non-redundantly quantify all types of sRNAs, and extract patterns of expression in biologically defined groups. We have used our tool to characterize and profile sRNAs in post-mortem brain samples of control individuals and Parkinson's disease (PD) cases at early-premotor and late-symptomatic stages.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Bioinformatics

Title: Bioinformatics (Oxford, England)

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1367-4811

ISSN (Print): 1367-4803

Publication date (Electronic): March 01 2016

Volume: 32

Issue: 5

Affiliations

[1 ] Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona 08003, Spain, Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain, IMIM, Hospital del Mar Medical Research Institute, Barcelona 08003, Spain, CIBER de Epidemiología y Salud Pública (CIBERESP), CRG, Instituto Carlos III Barcelona 08003, Spain, Universitat Autonoma de Barcelona, Institut de Biotecnologia i de Biomedicina, Bellaterra (Cerdanyola del Valles), Barcelona, Spain and.

[2 ] Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona 08003, Spain, Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain, IMIM, Hospital del Mar Medical Research Institute, Barcelona 08003, Spain, CIBER de Epidemiología y Salud Pública (CIBERESP), CRG, Instituto Carlos III Barcelona 08003, Spain.

[3 ] Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Spain and CIBER de Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Barcelona, Spain.

Article

Publisher Item ID: btv632

DOI: 10.1093/bioinformatics/btv632

PubMed ID: 26530722

SO-VID: 345ba42a-2f90-4997-a083-bd42852643a8

History

Data availability:

Comments

Comment on this article

scite_

Cited by 18

See all cited by