Phylogenetic Relationships and Classification of Didelphid Marsupials, an Extant Radiation of New World Metatherian Mammals

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Related collections

Most cited references 153

Record: found
Abstract: found
Article: not found

Biochemistry and genetics of von Willebrand factor.

J Sadler (1998)

Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis, and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited bleeding disorder. VWF mediates the adhesion of platelets to sites of vascular damage by binding to specific platelet membrane glycoproteins and to constituents of exposed connective tissue. These activities appear to be regulated by allosteric mechanisms and possibly by hydrodynamic shear forces. VWF also is a carrier protein for blood clotting factor VIII, and this interaction is required for normal factor VIII survival in the circulation. VWF is assembled from identical approximately 250 kDa subunits into disulfide-linked multimers that may be > 20,000 kDa. Mutations in VWD can disrupt this complex biosynthetic process at several steps to impair the assembly, intracellular targeting, or secretion of VWF multimers. Other VWD mutations impair the survival of VWF in plasma or the function of specific ligand binding sites. This growing body of information about VWF synthesis, structure, and function has allowed the reclassification of VWD based upon distinct pathophysiologic mechanisms that appear to correlate with clinical symptoms and the response to therapy.

0 comments Cited 233 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Reliability of Bayesian posterior probabilities and bootstrap frequencies in phylogenetics.

Bengt Oxelman, Tom Britton, Per Erixon … (2003)

Many empirical studies have revealed considerable differences between nonparametric bootstrapping and Bayesian posterior probabilities in terms of the support values for branches, despite claimed predictions about their approximate equivalence. We investigated this problem by simulating data, which were then analyzed by maximum likelihood bootstrapping and Bayesian phylogenetic analysis using identical models and reoptimization of parameter values. We show that Bayesian posterior probabilities are significantly higher than corresponding nonparametric bootstrap frequencies for true clades, but also that erroneous conclusions will be made more often. These errors are strongly accentuated when the models used for analyses are underparameterized. When data are analyzed under the correct model, nonparametric bootstrapping is conservative. Bayesian posterior probabilities are also conservative in this respect, but less so.

0 comments Cited 158 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

V(D)J recombination: RAG proteins, repair factors, and regulation.

Martin Gellert (2001)

V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting gene segments. Because there is a large choice of segments to join, this process accounts for much of the diversity of the immune response. Recombination is initiated by the lymphoid-specific RAG1 and RAG2 proteins, which cooperate to make double-strand breaks at specific recognition sequences (recombination signal sequences, RSSs). The neighboring coding DNA is converted to a hairpin during breakage. Broken ends are then processed and joined with the help of several factors also involved in repair of radiation-damaged DNA, including the DNA-dependent protein kinase (DNA-PK) and the Ku, Artemis, DNA ligase IV, and Xrcc4 proteins, and possibly histone H2AX and the Mre11/Rad50/Nbs1 complex. There may be other factors not yet known. V(D)J recombination is strongly regulated by limiting access to RSS sites within chromatin, so that particular sites are available only in certain cell types and developmental stages. The roles of enhancers, histone acetylation, and chromatin remodeling factors in controlling accessibility are discussed. The RAG proteins are also capable of transposing RSS-ended fragments into new DNA sites. This transposition helps to explain the mechanism of RAG action and supports earlier proposals that V(D)J recombination evolved from an ancient mobile DNA element.

0 comments Cited 143 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Bulletin of the American Museum of Natural History

Abbreviated Title: Bulletin of the American Museum of Natural History

Publisher: American Museum of Natural History (BioOne sponsored)

ISSN (Print): 0003-0090

Publication date Created: June 30 2009

Publication date (Print): June 30 2009

Volume: 322

Issue:

Pages: 1-177

Article

DOI: 10.1206/322.1

SO-VID: 3556cd64-ca04-44e6-a84c-4501112ce4eb

History

Data availability:

Comments

Comment on this article

scite_

Cited by 103

See all cited by

Most referenced authors 1,486

See all reference authors

Phylogenetic Relationships and Classification of Didelphid Marsupials, an Extant Radiation of New World Metatherian Mammals

Read this article at

Abstract

Related collections

High Entropy Alloys and Complex Concentrated Alloys

Most cited references 153

Biochemistry and genetics of von Willebrand factor.

Reliability of Bayesian posterior probabilities and bootstrap frequencies in phylogenetics.

V(D)J recombination: RAG proteins, repair factors, and regulation.

Author and article information

Journal

Article

History

Comments

Comment on this article

Similar content 1,781

Cited by 103

Most referenced authors 1,486