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      Effect of interferon-alpha, interferon-gamma and tumour necrosis factor on African swine fever virus replication in porcine monocytes and macrophages.

      1 , ,
      The Journal of general virology
      Microbiology Society

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          Abstract

          Bovine interferon-alpha I1 (IFN-alpha I1) and porcine interferon-gamma (IFN-gamma) inhibited African swine fever virus replication in both porcine monocytes and alveolar macrophages. The most potent antiviral activity was observed with IFN-gamma-treated alveolar macrophages. The production of both a virulent (CC83) and a non-virulent (BA71) isolate of the virus was inhibited. Bovine tumour necrosis factor alpha did not show antiviral activity in either monocytes or alveolar macrophages. Rather, an increase of African swine fever virus production in tumour necrosis factor alpha-treated monocytes was found. An analysis of viral protein synthesis in IFN-alpha I1- and IFN-gamma-treated alveolar macrophages showed an inhibition of synthesis of some viral proteins. The inhibition of late proteins was very pronounced in IFN-gamma-treated cells, and it was probably a consequence of the inhibition of African swine fever virus DNA polymerase activity.

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          Author and article information

          Journal
          J. Gen. Virol.
          The Journal of general virology
          Microbiology Society
          0022-1317
          0022-1317
          Dec 1988
          : 69 ( Pt 12)
          Affiliations
          [1 ] Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Canto Blanco, Madrid, Spain.
          Article
          10.1099/0022-1317-69-12-2973
          3143809
          357af621-21ec-4f21-879c-0662f80817ca
          History

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