- Record: found
- Abstract: not found
- Article: not found
Effects of guanethidine sympathectomy on feeding, drinking, weight gain and amphetamine anorexia in the rat
September 1985
September 1985
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Adult female rats that underwent sympathectomy induced by guanethidine treatment (10,
20 or 40 mg/kg) exhibited markedly increased water intake, but did not display significant
alterations of either food intake, body weight, or the Lee Index of obesity. Guanethidine
treatment did not attenuate amphetamine anorexia as evidenced by comparable dose-dependent
reductions in food intake to d-amphetamine sulfate (0.25, 0.50, 1.0, and 2.0 mg/kg)
in sympathectomized and control rats. These data are not consistent with the hypothesis
that amphetamine anorexia is partially mediated via enhanced BAT thermogenesis.