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      Fasting, circadian rhythms, and time restricted feeding in healthy lifespan

      research-article
      1 , 2 , 3
      Cell metabolism

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          Summary

          Feeding in most animals is confined to a defined period, leaving short periods of fasting that coincide with sleep. Fasting enables organisms to enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which feeding time is restricted to certain hours of the day, allows the daily fasting period to last >12 h, thus imparting pleiotropic benefits in multiple organisms. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMD, both basic science and translational research are warranted to develop fasting-associated interventions into effective and inexpensive treatments with the potential to improve healthspan.

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          Author and article information

          Journal
          101233170
          32527
          Cell Metab
          Cell Metab.
          Cell metabolism
          1550-4131
          1932-7420
          7 July 2016
          14 June 2016
          14 June 2017
          : 23
          : 6
          : 1048-1059
          Affiliations
          [1 ]Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
          [2 ]IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy
          [3 ]Regulatory Biology Laboratory, Salk institute for Biological Studies, La Jolla, CA 92037
          Author notes
          Article
          PMC5388543 PMC5388543 5388543 nihpa794279
          10.1016/j.cmet.2016.06.001
          5388543
          27304506
          36b9015c-36c6-4754-8cb2-1036797fa74e
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