Mateja M Jelen 1 , Zigui Chen 2 , Boštjan J Kocjan 3 , Lea Hošnjak 3 , Felicity J Burt 4 , Paul K S Chan 2 , Diego Chouhy 5 , Catharina E Combrinck 4 , Christine Estrade 6 , Alison Fiander 7 , Suzanne M Garland 8 , Adriana A Giri 5 , Joaquín Víctor González 9 , Arndt Gröning 10 , Sam Hibbitts 7 , Tommy N M Luk 11 , Karina Marinic 12 , Toshihiko Matsukura 13 , Anna Neumann 10 , Anja Oštrbenk 3 , Maria Alejandra Picconi 9 , Martin Sagadin 3 , Roland Sahli 6 , Riaz Y Seedat 14 , Katja Seme 3 , Alberto Severini 15 , Jessica L Sinchi 12 , Jana Smahelova 16 , Sepehr N Tabrizi 8 , Ruth Tachezy 16 , Sarah Tohme Faybush 15 , Virgilijus Uloza 17 , Ingrida Uloziene 17 , Yong Wee Wong 18 , Snježana Židovec Lepej 19 , Robert D Burk 20 , Mario Poljak 21
Jun 01 2016
Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B.