The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males☆

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Abstract

Background

Although apolipoprotein (apo) CIII gene polymorphisms have proved to be related to the increased serum lipid level in foreign studies, the results have not always been consistent among diverse populations. In addition, the research focuses on the impact of the apoCIII on the serum lipid levels of Han Chinese subjects which was not conducted before.

Objective

To explore the relationship between the apoCIII gene C3175G and T3206G polymorphisms and serum lipid levels as well as other risk factors for hyperlipidaemia, in Han Chinese males.

Method

A total of 337 healthy male participants undergoing physical examinations were randomly selected from two hospitals in Chongqing, China. Through DNA sequencing, apoCIII gene C3175G and T3206G polymorphisms were identified and their relationships with serum lipid levels were further analysed.

Results

Carriers of apoCIII ³¹⁷⁵ GG genotypes have higher levels of TG than other genotypes (P < 0.05). After the stratified selection of triacylglycerol (TG), G gene loci of apoCIIIT3206G are associated with decreasing the content of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) in relatively high TG group while the G gene loci of apoCIIIC3175G have an inverse effect. The outcome of TG unconditional logistic regression shows that the G gene loci of apoCIIIT3206G polymorphism are also beneficial for decreasing TG.

Conclusion

The detection of TG in apoCIII ³¹⁷⁵ GG genotype carriers is an efficient predictor of hypertriglyceridaemia in Han Chinese males. The G gene loci of apoCIII ³²⁰⁶ may be beneficial for decreasing serum lipid level.

Highlights

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Our research has tried its best to avoid all possible factors associated with lipids.
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The method has been adopted in new DNA sequencing.
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No previous similar research has worked on it, and we filled the gap.
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The outcome is accurate and exciting.

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Most cited references 7

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Apolipoprotein CIII and atherosclerosis: beyond effects on lipid metabolism.

Alex Bobik (2008)

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Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.

M W Tanck, Olga W. Souverein, S. Matthijs Boekholdt … (2005)

The objective of this paper was to identify the single nucleotide polymorphisms (SNPs) that show unshared effects on plasma triglyceride (TG) levels and to investigate whether these SNPs show statistically independent effects on plasma TG levels. In total, 59 polymorphisms in 20 genes involved in lipid metabolism were investigated. Polymorphisms were selected for a multivariate ANOVA model if they showed an univariate association with TG (after adjustment for HDL-C and LDL-C) in more than 50% of bootstrap samples that were made from the original data. The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). The gene variants APOA1 G(-75)A (P=0.04) and LPL Asn291Ser (P=0.03) were significantly associated with plasma TG levels in this multivariate analysis. The eight polymorphisms explained 8.9% of the variation in plasma TG levels. In conclusion, this study showed statistically independent effects of gene variants in the APOA1 and LPL genes on fasting plasma levels of TG. Nevertheless, only a small part of variation in TG levels could be explained by the polymorphisms.

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The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study.

Bart P Leroy, Bernard Herbeth, S Gueguen … (2007)

Carotenoids are mainly carried by lipoproteins in blood, however little is known about the influence of polymorphisms of apolipoproteins (apo), cholesterol ester transfer protein (CETP) and lipoprotein lipase (LPL) involved in serum lipid metabolism. We aimed to analyze whether serum concentrations of 5 carotenoids (lutein-zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene) are associated with common polymorphisms of Apo E, Apo B, Apo CIII, CETP, and LPL. Serum concentrations of lutein-zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and beta-carotene were measured and polymorphisms of Apo E (cys112arg and arg158cys), Apo B (thr71ile), Apo CIII [C(-482)T, Apo CIII T(-455)C, Apo CIII C1100T, Apo CIII C3175G, Apo CIII T3206G], CETP (ile405val), and LPL (S447X) were determined in a sample of 447 children and adults drawn from the Stanislas Study. After adjustment for age, sex, smoking, physical activity, oral contraceptive use, BMI, serum cholesterol and triglyceride concentrations, and fruit and vegetable intakes, carriers vs. non carriers of the lipoprotein lipase X447 allele had significant lower concentrations of lutein-zeaxanthin, beta-cryptoxanthin, alpha-carotene and beta-carotene; differences vs. S447S genotype being the largest for X447X: -18.8%, -50.5%, -54.8% and -47.1%, for the four carotenoid fractions, respectively. No significant association was noticed for lycopene concentration. None of the other tested polymorphisms was significantly related to the serum carotenoid concentrations. Our investigation for the first time demonstrates that LPL S447X polymorphism could alter serum concentrations of carotenoids in healthy individuals, independently of serum cholesterol and triglyceride concentration. These data indicate that genetic factors could be involved in the variability of carotenoid bioavailability and bioconversion.

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Author and article information

Contributors

Xiaojun Tang

Journal

Journal ID (nlm-ta): Meta Gene

Journal ID (iso-abbrev): Meta Gene

Title: Meta Gene

Publisher: Elsevier

ISSN (Electronic): 2214-5400

Publication date PMC-release: 15 November 2013

Publication date Collection: December 2013

Publication date (Electronic): 15 November 2013

Volume: 1

Pages: 58-64

Affiliations

[a ]School of Public Health and Management, Chongqing Medical University, Chongqing, China

[b ]Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden

[c ]College of Laboratory Medicine, Chongqing Medical University, Chongqing, China

[d ]The First People's Hospital of Jiulongpo District, Chongqing, China

[e ]Chonggang Hospital, Chongqing, China

Author notes

[* ]Corresponding author. tangxiaoj0726@ 123456qq.com

Article

Publisher ID: S2214-5400(13)00007-8

DOI: 10.1016/j.mgene.2013.09.005

PMC ID: 4205029

SO-VID: 370627bf-8e5e-46cd-8441-0cb2e67bcbf3

History

Date received : 20 September 2013

Date accepted : 21 September 2013

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